REG1A


Summary: This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
regenerating family member 1 alphaMIM:167770Ensembl:ENSG00000115386HGNC:HGNC:9951PA343182p12

GO terms in REG1A


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0006952defense response
BPIBAGO:0008284positive regulation of cell proliferation
BPTASGO:0008284positive regulation of cell proliferation
BPIEAGO:0010469regulation of signaling receptor activity
BPIBAGO:0043434response to peptide hormone
BPIBAGO:0044278cell wall disruption in other organism
BPIBAGO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide
CCIBAGO:0005615extracellular space
CCHDAGO:0070062extracellular exosome
MFIBAGO:0004888transmembrane signaling receptor activity
MFIDAGO:0008083growth factor activity
MFIEAGO:0030246carbohydrate binding
MFIBAGO:0042834peptidoglycan binding
MFIBAGO:0070492oligosaccharide binding

Gene expression in normal tissue: REG1A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in REG1A


DatabasePathway IDPathway Des.
wikipathwaysWP481Insulin Signaling
wikipathwaysWP619Type II interferon signaling (IFNG)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD190Nilotinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in REG1A

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