Summary: This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008].


GO terms in RELN

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0008236serine-type peptidase activity
MFIEAGO:0046872metal ion binding
MFISSGO:0070325lipoprotein particle receptor binding
MFISSGO:0070326very-low-density lipoprotein particle receptor binding
CCTASGO:0005576extracellular region
CCISSGO:0005615extracellular space
CCIEAGO:0005886plasma membrane
BPISSGO:0000904cell morphogenesis involved in differentiation
BPISSGO:0001764neuron migration
BPIEAGO:0007155cell adhesion
BPISSGO:0007411axon guidance
BPTASGO:0007411axon guidance
BPISSGO:0007417central nervous system development
BPISSGO:0007420brain development
BPIEAGO:0007616long-term memory
BPIEAGO:0008306associative learning
BPISSGO:0010001glial cell differentiation
BPISSGO:0010976positive regulation of neuron projection development
BPIEAGO:0014068positive regulation of phosphatidylinositol 3-kinase signaling
BPIEAGO:0016358dendrite development
BPISSGO:0018108peptidyl-tyrosine phosphorylation
BPISSGO:0021511spinal cord patterning
BPIEAGO:0021517ventral spinal cord development
BPISSGO:0021766hippocampus development
BPISSGO:0021800cerebral cortex tangential migration
BPIEAGO:0021819layer formation in cerebral cortex
BPIEAGO:0032008positive regulation of TOR signaling
BPISSGO:0032793positive regulation of CREB transcription factor activity
BPIEAGO:0035418protein localization to synapse
BPISSGO:0038026reelin-mediated signaling pathway
BPISSGO:0045860positive regulation of protein kinase activity
BPISSGO:0048265response to pain
BPISSGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPISSGO:0050795regulation of behavior
BPISSGO:0050804modulation of chemical synaptic transmission
BPISSGO:0051057positive regulation of small GTPase mediated signal transduction
BPISSGO:0051968positive regulation of synaptic transmission, glutamatergic
BPIEAGO:0060291long-term synaptic potentiation
BPISSGO:0061003positive regulation of dendritic spine morphogenesis
BPISSGO:0061098positive regulation of protein tyrosine kinase activity
BPISSGO:0090129positive regulation of synapse maturation
BPIEAGO:0097114NMDA glutamate receptor clustering
BPIEAGO:0097119postsynaptic density protein 95 clustering
BPIEAGO:0097120receptor localization to synapse
BPIEAGO:0097477lateral motor column neuron migration
BPISSGO:1900273positive regulation of long-term synaptic potentiation
BPIEAGO:1902078positive regulation of lateral motor column neuron migration
BPISSGO:2000310regulation of NMDA receptor activity
BPISSGO:2000463positive regulation of excitatory postsynaptic potential
BPISSGO:2000969positive regulation of AMPA receptor activity

Gene expression in normal tissue: RELN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RELN

DatabasePathway IDPathway Des.
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
pidlis1pathwayLissencephaly gene (LIS1) in neuronal migration and development
pidreelinpathwayReelin signaling pathway
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04512ECM-receptor interaction - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
biocartalis1pathwaylissencephaly gene (lis1) in neuronal migration and development
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-8866376Reelin signalling pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RELN