RXRG


Summary: This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
retinoid X receptor gammaMIM:180247Ensembl:ENSG00000143171HGNC:HGNC:10479PA348921q23.3

GO terms in RXRG


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005654nucleoplasm
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIEAGO:0043401steroid hormone mediated signaling pathway
BPIEAGO:0048384retinoic acid receptor signaling pathway
BPIEAGO:0051289protein homotetramerization
BPIEAGO:1901522positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
MFIEAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0003707steroid hormone receptor activity
MFIEAGO:00048869-cis retinoic acid receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding

Gene expression in normal tissue: RXRG

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RXRG


DatabasePathway IDPathway Des.
wikipathwaysWP170Nuclear Receptors
wikipathwaysWP236Adipogenesis
wikipathwaysWP3942PPAR signaling pathway
wikipathwaysWP716Vitamin A and Carotenoid Metabolism
kegghsa03320PPAR signaling pathway - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
pida6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
pidar_tf_pathwayRegulation of Androgen receptor activity
pidretinoic_acid_pathwayRetinoic acid receptors-mediated signaling
pidrxr_vdr_pathwayRXR and RAR heterodimerization with other nuclear receptor
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-383280Nuclear Receptor transcription pathway
reactomeR-HSA-5362517Signaling by Retinoic Acid
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-9006931Signaling by Nuclear Receptors

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD536PLX-47201

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RXRG

​​​​