SAP30
Summary: Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Sin3A associated protein 30 | MIM:603378 | Ensembl:ENSG00000164105 | HGNC:HGNC:10532 | PA34941 | 4q34.1 |
Gene Categories:
HISTONE MODIFICATIONGO terms in SAP30
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IDA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0016575 | histone deacetylation |
| BP | IEA | GO:0035914 | skeletal muscle cell differentiation |
| CC | IBA | GO:0000118 | histone deacetylase complex |
| CC | IDA | GO:0000118 | histone deacetylase complex |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003712 | transcription coregulator activity |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | IBA | GO:0004407 | histone deacetylase activity |
| MF | TAS | GO:0004407 | histone deacetylase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: SAP30
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SAP30
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-3214815 | HDACs deacetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-427413 | NoRC negatively regulates rRNA expression |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP61 | Notch Signaling Pathway |
| netpath | Pathway_Notch | Notch |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| pid | telomerasepathway | Regulation of Telomerase |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SAP30
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.