SEC61A2
Summary: The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Sec61 translocon alpha 2 subunit | Ensembl:ENSG00000065665 | HGNC:HGNC:17702 | PA134861382 | 10p14 |
GO terms in SEC61A2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IBA | GO:0005048 | signal sequence binding |
| MF | IBA | GO:0008320 | protein transmembrane transporter activity |
| MF | IEA | GO:0043022 | ribosome binding |
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | IBA | GO:0005784 | Sec61 translocon complex |
| CC | IBA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | IBA | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation |
| BP | IBA | GO:0006620 | posttranslational protein targeting to endoplasmic reticulum membrane |
| BP | ND | GO:0008150 | biological_process |
| BP | IEA | GO:0015031 | protein transport |
Gene expression in normal tissue: SEC61A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SEC61A2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03060 | Protein export - Homo sapiens (human) |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa05110 | Vibrio cholerae infection - Homo sapiens (human) |
| reactome | R-HSA-1236974 | ER-Phagosome pathway |
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
| reactome | R-HSA-381038 | XBP1(S) activates chaperone genes |
| reactome | R-HSA-381070 | IRE1alpha activates chaperones |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SEC61A2
CLASSFICATION
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