SEZ6


Summary: The protein encoded by this gene is thought to contain five cysteine-rich motifs that are similar to sushi domains, as well as two domains similar to the amino terminal half of the CUB (for complement C1r/C1s, Uegf, Bmp1) domain. Mutations in this gene have been associated with febrile seizures. [provided by RefSeq, Jul 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
seizure related 6 homologMIM:616666Ensembl:ENSG00000063015HGNC:HGNC:15955PA3806517q11.2

GO terms in SEZ6


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0008344adult locomotory behavior
BPIEAGO:0021680cerebellar Purkinje cell layer development
BPIEAGO:0060074synapse maturation
BPIEAGO:0060079excitatory postsynaptic potential
BPIEAGO:0090036regulation of protein kinase C signaling
BPIEAGO:1900006positive regulation of dendrite development
BPIEAGO:2000171negative regulation of dendrite development
CCIEAGO:0005615extracellular space
CCIEAGO:0005783endoplasmic reticulum
CCIEAGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCIEAGO:0043025neuronal cell body
CCIEAGO:0043197dendritic spine
CCIEAGO:0043198dendritic shaft
CCIEAGO:0048471perinuclear region of cytoplasm
CCIEAGO:0097440apical dendrite

Gene expression in normal tissue: SEZ6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SEZ6


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib1
iGMDRD353PD03259011
iGMDRD30917AAG2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SEZ6

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