SLAMF6
Summary: The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
SLAM family member 6 | MIM:606446 | Ensembl:ENSG00000162739 | HGNC:HGNC:21392 | PA134959277 | 1q23.2-q23.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in SLAMF6
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
BP | IMP | GO:0032729 | positive regulation of interferon-gamma production |
BP | IDA | GO:0032740 | positive regulation of interleukin-17 production |
BP | IEA | GO:0045087 | innate immune response |
BP | IDA | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity |
BP | TAS | GO:0050776 | regulation of immune response |
BP | IDA | GO:0072540 | T-helper 17 cell lineage commitment |
CC | IDA | GO:0005886 | plasma membrane |
CC | TAS | GO:0005886 | plasma membrane |
CC | IEA | GO:0016021 | integral component of membrane |
CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: SLAMF6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLAMF6
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1280218 | Adaptive Immune System |
reactome | R-HSA-168256 | Immune System |
reactome | R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
netpath | Pathway_TCR | TCR |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLAMF6