Summary: The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011].

solute carrier family 20 member 1MIM:137570Ensembl:ENSG00000144136HGNC:HGNC:10946PA358332q14.1

Gene Categories:


GO terms in SLC20A1

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006796phosphate-containing compound metabolic process
BPTASGO:0006811ion transport
BPIEAGO:0007165signal transduction
BPIBAGO:0035435phosphate ion transmembrane transport
BPIEAGO:0035725sodium ion transmembrane transport
BPHMPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0044341sodium-dependent phosphate transport
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
MFIBAGO:0005315inorganic phosphate transmembrane transporter activity
MFIEAGO:0005316high-affinity inorganic phosphate:sodium symporter activity
MFTASGO:0005436sodium:phosphate symporter activity
MFIBAGO:0015319sodium:inorganic phosphate symporter activity
MFTASGO:0015321sodium-dependent phosphate transmembrane transporter activity
MFTASGO:0038023signaling receptor activity

Gene expression in normal tissue: SLC20A1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLC20A1

DatabasePathway IDPathway Des.
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptides
reactomeR-HSA-425407SLC-mediated transmembrane transport
reactomeR-HSA-427652Sodium-coupled phosphate cotransporters

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC20A1