SLC20A1
Summary: The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 20 member 1 | MIM:137570 | Ensembl:ENSG00000144136 | HGNC:HGNC:10946 | PA35833 | 2q14.1 |
Gene Categories:
TRANSPORTERGO terms in SLC20A1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006796 | phosphate-containing compound metabolic process |
| BP | TAS | GO:0006811 | ion transport |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IBA | GO:0035435 | phosphate ion transmembrane transport |
| BP | IEA | GO:0035725 | sodium ion transmembrane transport |
| BP | HMP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0044341 | sodium-dependent phosphate transport |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0016020 | membrane |
| MF | IBA | GO:0005315 | inorganic phosphate transmembrane transporter activity |
| MF | IEA | GO:0005316 | high-affinity inorganic phosphate:sodium symporter activity |
| MF | TAS | GO:0005436 | sodium:phosphate symporter activity |
| MF | IBA | GO:0015319 | sodium:inorganic phosphate symporter activity |
| MF | TAS | GO:0015321 | sodium-dependent phosphate transmembrane transporter activity |
| MF | TAS | GO:0038023 | signaling receptor activity |
Gene expression in normal tissue: SLC20A1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC20A1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425393 | Transport of inorganic cations/anions and amino acids/oligopeptides |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-427652 | Sodium-coupled phosphate cotransporters |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC20A1
CLASSFICATION
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