SLC25A6


Summary: This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
solute carrier family 25 member 6MIM:403000Ensembl:ENSG00000169100HGNC:HGNC:10992PA35868Xp22.33 and Yp11.2

GO terms in SLC25A6


Term TypeEvidence TypeGO Term IDGO Des.
CCHDAGO:0005634nucleus
CCHDAGO:0005739mitochondrion
CCIDAGO:0005739mitochondrion
CCTASGO:0005743mitochondrial inner membrane
CCTASGO:0005744mitochondrial inner membrane presequence translocase complex
BPTASGO:0006626protein targeting to mitochondrion
BPIEAGO:0006915apoptotic process
BPIEAGO:0015853adenine transport
BPIEAGO:0015866ADP transport
BPIEAGO:0015867ATP transport
BPTASGO:0046732active induction of host immune response by virus
BPIBAGO:0046902regulation of mitochondrial membrane permeability
BPTASGO:0050796regulation of insulin secretion
BPIEAGO:0055085transmembrane transport
MFIBAGO:0005471ATP:ADP antiporter activity
MFNASGO:0005471ATP:ADP antiporter activity
MFIPIGO:0005515protein binding
MFTASGO:0015207adenine transmembrane transporter activity

Gene expression in normal tissue: SLC25A6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLC25A6


DatabasePathway IDPathway Des.
reactomeR-HSA-1268020Mitochondrial protein import
reactomeR-HSA-1268020Mitochondrial protein import
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-162909Host Interactions of HIV factors
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-1643685Disease
reactomeR-HSA-168253Host Interactions with Influenza Factors
reactomeR-HSA-168254Influenza Infection
reactomeR-HSA-168277Influenza Virus Induced Apoptosis
reactomeR-HSA-176033Interactions of Vpr with host cellular proteins
reactomeR-HSA-180897Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-5663205Infectious disease
wikipathwaysWP111Electron Transport Chain
netpathPathway_EGFR1EGFR1
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa05012Parkinson,s disease - Homo sapiens (human)
kegghsa05016Huntington,s disease - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD748PHA-6657521

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC25A6

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