SLC6A20


Summary: Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene is a member of the subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter family. This gene is expressed in kidney, and its alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
solute carrier family 6 member 20MIM:605616Ensembl:ENSG00000163817HGNC:HGNC:30927PA1348653083p21.31

GO terms in SLC6A20


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005215transporter activity
MFIEAGO:0005328neurotransmitter:sodium symporter activity
MFIPIGO:0005515protein binding
MFIDAGO:0015171amino acid transmembrane transporter activity
MFTASGO:0015171amino acid transmembrane transporter activity
MFIBAGO:0015193L-proline transmembrane transporter activity
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCISSGO:0016324apical plasma membrane
CCIEAGO:0031526brush border membrane
BPIEAGO:0003333amino acid transmembrane transport
BPIDAGO:0006865amino acid transport
BPTASGO:0006865amino acid transport
BPIMPGO:0015816glycine transport
BPIMPGO:0015824proline transport
BPIBAGO:0035725sodium ion transmembrane transport

Gene expression in normal tissue: SLC6A20

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLC6A20


DatabasePathway IDPathway Des.
reactomeR-HSA-1643685Disease
reactomeR-HSA-352230Amino acid transport across the plasma membrane
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-425366Transport of bile salts and organic acids, metal ions and amine compounds
reactomeR-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptides
reactomeR-HSA-425407SLC-mediated transmembrane transport
reactomeR-HSA-442660Na+/Cl- dependent neurotransmitter transporters
reactomeR-HSA-5619101Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)
reactomeR-HSA-5619102SLC transporter disorders
reactomeR-HSA-5619115Disorders of transmembrane transporters
reactomeR-HSA-5660686Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
smpdbSMP00078Chlorothiazide Action Pathway
smpdbSMP00080Polythiazide Action Pathway
smpdbSMP00081Methyclothiazide Action Pathway
smpdbSMP00088Bumetanide Action Pathway
smpdbSMP00090Bendroflumethiazide Action Pathway
smpdbSMP00091Quinethazone Action Pathway
smpdbSMP00097Ethacrynic Acid Action Pathway
smpdbSMP00100Hydrochlorothiazide Action Pathway
smpdbSMP00103Cyclothiazide Action Pathway
smpdbSMP00105Metolazone Action Pathway
smpdbSMP00108Hydroflumethiazide Action Pathway
smpdbSMP00110Indapamide Action Pathway
smpdbSMP00115Furosemide Action Pathway
smpdbSMP00118Torsemide Action Pathway
smpdbSMP00121Trichlormethiazide Action Pathway
smpdbSMP00122Chlorthalidone Action Pathway
smpdbSMP00132Triamterene Action Pathway
smpdbSMP00133Amiloride Action Pathway
smpdbSMP00134Spironolactone Action Pathway
smpdbSMP00135Eplerenone Action Pathway
smpdbSMP00184Glucose Transporter Defect (SGLT2)
smpdbSMP00189Hartnup Disorder
smpdbSMP00193Iminoglycinuria
smpdbSMP00197Lysinuric Protein Intolerance
smpdbSMP00245Glucose Transporter Defect (SGLT2)
smpdbSMP00483Kidney Function
smpdbSMP00583Blue diaper syndrome
smpdbSMP00585Lysinuric protein intolerance (LPI)
smpdbSMP00723Cystinuria

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD491TAE-6841
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC6A20

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