Summary: This gene encodes a multi-pass membrane protein that is a member of a family of sodium and chloride-ion dependent transporters. The encoded protein transports taurine and beta-alanine. There is a pseudogene for this gene on chromosome 21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].

solute carrier family 6 member 6MIM:186854Ensembl:ENSG00000131389HGNC:HGNC:11052PA359123p25.1

GO terms in SLC6A6

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005215transporter activity
MFIEAGO:0005328neurotransmitter:sodium symporter activity
MFIBAGO:0005369taurine:sodium symporter activity
MFTASGO:0015171amino acid transmembrane transporter activity
BPTASGO:0006520cellular amino acid metabolic process
BPIEAGO:0006836neurotransmitter transport
BPTASGO:0006865amino acid transport
BPIBAGO:0015734taurine transport
BPIBAGO:0035725sodium ion transmembrane transport
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0016021integral component of membrane

Gene expression in normal tissue: SLC6A6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLC6A6

DatabasePathway IDPathway Des.
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
reactomeR-HSA-352230Amino acid transport across the plasma membrane
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-425366Transport of bile salts and organic acids, metal ions and amine compounds
reactomeR-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptides
reactomeR-HSA-425407SLC-mediated transmembrane transport
reactomeR-HSA-442660Na+/Cl- dependent neurotransmitter transporters

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC6A6