SLC6A6
Summary: This gene encodes a multi-pass membrane protein that is a member of a family of sodium and chloride-ion dependent transporters. The encoded protein transports taurine and beta-alanine. There is a pseudogene for this gene on chromosome 21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:186854 Ensembl IDEnsembl:ENSG00000131389 HGNC IDHGNC:HGNC:11052 PHARMGKB IDPA35912 Map Location3p25.1 |
GO terms in SLC6A6
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0005215 | transporter activity |
MF | IEA | GO:0005328 | neurotransmitter:sodium symporter activity |
MF | IBA | GO:0005369 | taurine:sodium symporter activity |
MF | TAS | GO:0015171 | amino acid transmembrane transporter activity |
BP | TAS | GO:0006520 | cellular amino acid metabolic process |
BP | IEA | GO:0006836 | neurotransmitter transport |
Gene expression in normal tissue: SLC6A6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC6A6
Loading, please wait...
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
wikipathways | WP2884 | NRF2 pathway |
reactome | R-HSA-352230 | Amino acid transport across the plasma membrane |
reactome | R-HSA-382551 | Transport of small molecules |
reactome | R-HSA-425366 | Transport of bile salts and organic acids, metal ions and amine compounds |
reactome | R-HSA-425393 | Transport of inorganic cations/anions and amino acids/oligopeptides |
Gene-Drug: Aster Plot
Loading, please wait...
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD409 | Saracatinib | 1 |
Showing 1 to 1 of 1 rows
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC6A6
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |