SLC7A14


Summary: This gene is predicted to encode a glycosylated, cationic amino acid transporter protein with 14 transmembrane domains. This gene is primarily expressed in skin fibroblasts, neural tissue, and primary endothelial cells and its protein is predicted to mediate lysosomal uptake of cationic amino acids. Mutations in this gene are associated with autosomal recessive retinitis pigmentosa. In mice, this gene is expressed in the photoreceptor layer of the retina where its expression increases over the course of retinal development and persists in the mature retina. [provided by RefSeq, Apr 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
solute carrier family 7 member 14MIM:615720Ensembl:ENSG00000013293HGNC:HGNC:29326PA1426709133q26.2

GO terms in SLC7A14


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005765lysosomal membrane
CCIEAGO:0016021integral component of membrane
BPIEAGO:0006865amino acid transport
BPIDAGO:0010923negative regulation of phosphatase activity
BPIEAGO:0055085transmembrane transport
MFIEAGO:0022857transmembrane transporter activity

Gene expression in normal tissue: SLC7A14

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLC7A14


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011
iGMDRD30917AAG1
iGMDRD399Selumetinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC7A14

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