Summary: Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008].


GO terms in SLN

Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0004857enzyme inhibitor activity
MFIPIGO:0005515protein binding
MFISSGO:0051117ATPase binding
BPNASGO:0006816calcium ion transport
BPISSGO:0043086negative regulation of catalytic activity
BPISSGO:0043242negative regulation of protein complex disassembly
BPISSGO:0051924regulation of calcium ion transport
BPISSGO:0070296sarcoplasmic reticulum calcium ion transport
BPISSGO:0090281negative regulation of calcium ion import
BPISSGO:1901020negative regulation of calcium ion transmembrane transporter activity
BPISSGO:1901077regulation of relaxation of muscle
BPISSGO:1901877negative regulation of calcium ion binding
BPISSGO:1901881positive regulation of protein depolymerization
BPIDAGO:1901894regulation of calcium-transporting ATPase activity
CCNASGO:0016021integral component of membrane
CCIDAGO:0016529sarcoplasmic reticulum
CCISSGO:0033017sarcoplasmic reticulum membrane

Gene expression in normal tissue: SLN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLN

DatabasePathway IDPathway Des.
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5578775Ion homeostasis
reactomeR-HSA-936837Ion transport by P-type ATPases
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLN