Summary: This gene encodes a member of the SWI/SNF family of proteins. The encoded protein is an ATPase which is expressed in diverse tissues and contributes to the chromatin remodeling complex that is involved in transcription. The protein may also play a role in DNA damage, growth inhibition and apoptosis of cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1MIM:300012Ensembl:ENSG00000102038HGNC:HGNC:11097PA35947Xq25-q26.1

GO terms in SMARCA1

Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0016589NURF complex
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIDAGO:0090537CERF complex
BPIEAGO:0000733DNA strand renaturation
BPIDAGO:0006338chromatin remodeling
BPIMPGO:0006351transcription, DNA-templated
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPIMPGO:0007420brain development
BPISSGO:0030182neuron differentiation
BPIDAGO:0043044ATP-dependent chromatin remodeling
BPIMPGO:0045893positive regulation of transcription, DNA-templated
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0003677DNA binding
MFIEAGO:0004386helicase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0008094DNA-dependent ATPase activity
MFIPIGO:0008134transcription factor binding
MFIEAGO:0031491nucleosome binding
MFIDAGO:0036310annealing helicase activity
MFIDAGO:0070615nucleosome-dependent ATPase activity

Gene expression in normal tissue: SMARCA1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SMARCA1

DatabasePathway IDPathway Des.
wikipathwaysWP2882Nuclear Receptors Meta-Pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD907EZH2 inhibitor1
iGMDRD908EZH2 inhibitor in RAS wt1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SMARCA1