SMARCA1
Summary: This gene encodes a member of the SWI/SNF family of proteins. The encoded protein is an ATPase which is expressed in diverse tissues and contributes to the chromatin remodeling complex that is involved in transcription. The protein may also play a role in DNA damage, growth inhibition and apoptosis of cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | MIM:300012 | Ensembl:ENSG00000102038 | HGNC:HGNC:11097 | PA35947 | Xq25-q26.1 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in SMARCA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0016589 | NURF complex |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IDA | GO:0090537 | CERF complex |
| BP | IEA | GO:0000733 | DNA strand renaturation |
| BP | IDA | GO:0006338 | chromatin remodeling |
| BP | IMP | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0007420 | brain development |
| BP | ISS | GO:0030182 | neuron differentiation |
| BP | IDA | GO:0043044 | ATP-dependent chromatin remodeling |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0004386 | helicase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0008094 | DNA-dependent ATPase activity |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0031491 | nucleosome binding |
| MF | IDA | GO:0036310 | annealing helicase activity |
| MF | IDA | GO:0070615 | nucleosome-dependent ATPase activity |
Gene expression in normal tissue: SMARCA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD907 | EZH2 inhibitor | 1 |
| iGMDRD908 | EZH2 inhibitor in RAS wt | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SMARCA1
CLASSFICATION
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