SSTR2


Summary: Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
somatostatin receptor 2MIM:182452Ensembl:ENSG00000180616HGNC:HGNC:11331PA3615517q25.1

GO terms in SSTR2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006937regulation of muscle contraction
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIBAGO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
BPTASGO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
BPIEAGO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
BPIBAGO:0007218neuropeptide signaling pathway
BPIEAGO:0007218neuropeptide signaling pathway
BPIEAGO:0007283spermatogenesis
BPTASGO:0008285negative regulation of cell proliferation
BPIEAGO:0021549cerebellum development
BPIEAGO:0030432peristalsis
BPIEAGO:0030900forebrain development
BPIEAGO:0038170somatostatin signaling pathway
BPIEAGO:0042594response to starvation
BPIBAGO:0071385cellular response to glucocorticoid stimulus
BPIBAGO:0071392cellular response to estradiol stimulus
CCIDAGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIBAGO:0043005neuron projection
MFIBAGO:0004930G-protein coupled receptor activity
MFIBAGO:0004994somatostatin receptor activity
MFIPIGO:0005515protein binding
MFIPIGO:0030165PDZ domain binding
MFIBAGO:0042277peptide binding
MFIBAGO:0042923neuropeptide binding

Gene expression in normal tissue: SSTR2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SSTR2


DatabasePathway IDPathway Des.
pharmgkbPA152530845Proton Pump Inhibitor Pathway, Pharmacodynamics
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04971Gastric acid secretion - Homo sapiens (human)
wikipathwaysWP117GPCRs, Other
wikipathwaysWP24Peptide GPCRs
wikipathwaysWP455GPCRs, Class A Rhodopsin-like
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375276Peptide ligand-binding receptors
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-500792GPCR ligand binding

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib1
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SSTR2

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