STAP1


Summary: The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
signal transducing adaptor family member 1MIM:604298Ensembl:ENSG00000035720HGNC:HGNC:24133PA1624049484q13.2

Gene Categories:

TYROSINE KINASEKINASE

GO terms in STAP1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005739mitochondrion
CCIDAGO:0032991protein-containing complex
CCIDAGO:0043231intracellular membrane-bounded organelle
BPISSGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPISSGO:0010628positive regulation of gene expression
BPISSGO:0010760negative regulation of macrophage chemotaxis
BPISSGO:0042326negative regulation of phosphorylation
BPIDAGO:0050861positive regulation of B cell receptor signaling pathway
BPISSGO:0060100positive regulation of phagocytosis, engulfment
BPISSGO:0071222cellular response to lipopolysaccharide
BPISSGO:1900028negative regulation of ruffle assembly
BPISSGO:1902227negative regulation of macrophage colony-stimulating factor signaling pathway
BPISSGO:1903980positive regulation of microglial cell activation
BPIDAGO:1903997positive regulation of non-membrane spanning protein tyrosine kinase activity
BPIEAGO:1904140negative regulation of microglial cell migration
BPISSGO:1904151positive regulation of microglial cell mediated cytotoxicity
BPISSGO:2000251positive regulation of actin cytoskeleton reorganization
MFIPIGO:0001784phosphotyrosine residue binding
MFISSGO:0005068transmembrane receptor protein tyrosine kinase adaptor activity
MFIPIGO:0005070SH3/SH2 adaptor activity
MFIEAGO:0005157macrophage colony-stimulating factor receptor binding
MFIPIGO:0005515protein binding
MFNASGO:0005543phospholipid binding
MFIPIGO:0019901protein kinase binding

Gene expression in normal tissue: STAP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STAP1


DatabasePathway IDPathway Des.
netpathPathway_BCRBCR
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD491TAE-6841
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STAP1

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