SYN1


Summary: This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
synapsin IMIM:313440Ensembl:ENSG00000008056HGNC:HGNC:11494PA36276Xp11.3-p11.23

Gene Categories:

TRANSPORTER

GO terms in SYN1


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0007268chemical synaptic transmission
BPIBAGO:0007269neurotransmitter secretion
BPIEAGO:0007269neurotransmitter secretion
BPTASGO:0046928regulation of neurotransmitter secretion
BPIEAGO:0097091synaptic vesicle clustering
BPNASGO:2000300regulation of synaptic vesicle exocytosis
CCIEAGO:0000795synaptonemal complex
CCIEAGO:0005794Golgi apparatus
CCIEAGO:0005829cytosol
CCIDAGO:0005856cytoskeleton
CCTASGO:0008021synaptic vesicle
CCIEAGO:0014069postsynaptic density
CCIEAGO:0030054cell junction
CCIEAGO:0030424axon
CCIEAGO:0030425dendrite
CCIBAGO:0030672synaptic vesicle membrane
CCIEAGO:0043209myelin sheath
CCIEAGO:0048786presynaptic active zone
CCIEAGO:0098993anchored component of synaptic vesicle membrane
MFIEAGO:0003779actin binding
MFTASGO:0005215transporter activity
MFIPIGO:0005515protein binding
MFTASGO:0005524ATP binding
MFISSGO:0019901protein kinase binding
MFIEAGO:0048306calcium-dependent protein binding

Gene expression in normal tissue: SYN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SYN1


DatabasePathway IDPathway Des.
wikipathwaysWP2267Synaptic Vesicle Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP727Monoamine Transport
reactomeR-HSA-112310Neurotransmitter release cycle
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-181429Serotonin Neurotransmitter Release Cycle
reactomeR-HSA-212676Dopamine Neurotransmitter Release Cycle

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib1
iGMDRD353PD03259011
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SYN1

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