Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].

TATA-box binding protein associated factor 6MIM:602955Ensembl:ENSG00000106290HGNC:HGNC:11540PA363157q22.1

GO terms in TAF6

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0001102RNA polymerase II activating transcription factor binding
MFIDAGO:0003677DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIDAGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIPIGO:0017162aryl hydrocarbon receptor binding
MFIEAGO:0046982protein heterodimerization activity
CCIBAGO:0000124SAGA complex
CCIEAGO:0000124SAGA complex
CCIBAGO:0005669transcription factor TFIID complex
CCIDAGO:0005669transcription factor TFIID complex
CCIMPGO:0032991protein-containing complex
CCIDAGO:0033276transcription factor TFTC complex
CCIEAGO:0046695SLIK (SAGA-like) complex
CCIDAGO:0071339MLL1 complex
BPIBAGO:0006325chromatin organization
BPIDAGO:0006352DNA-templated transcription, initiation
BPIBAGO:0006366transcription by RNA polymerase II
BPNASGO:0006366transcription by RNA polymerase II
BPTASGO:0006366transcription by RNA polymerase II
BPIDAGO:0006367transcription initiation from RNA polymerase II promoter
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPTASGO:0042795snRNA transcription by RNA polymerase II
BPIDAGO:0045786negative regulation of cell cycle
BPIEAGO:0051090regulation of DNA-binding transcription factor activity
BPIBAGO:0051123RNA polymerase II transcriptional preinitiation complex assembly
BPTASGO:1901796regulation of signal transduction by p53 class mediator

Gene expression in normal tissue: TAF6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TAF6

DatabasePathway IDPathway Des.
reactomeR-HSA-162587HIV Life Cycle
reactomeR-HSA-162599Late Phase of HIV Life Cycle
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-167161HIV Transcription Initiation
reactomeR-HSA-167162RNA Polymerase II HIV Promoter Escape
reactomeR-HSA-167172Transcription of the HIV genome
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-674695RNA Polymerase II Pre-transcription Events
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-6807505RNA polymerase II transcribes snRNA genes
reactomeR-HSA-6807505RNA polymerase II transcribes snRNA genes
reactomeR-HSA-73776RNA Polymerase II Promoter Escape
reactomeR-HSA-73779RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75953RNA Polymerase II Transcription Initiation
reactomeR-HSA-76042RNA Polymerase II Transcription Initiation And Promoter Clearance
wikipathwaysWP405Eukaryotic Transcription Initiation
kegghsa03022Basal transcription factors - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TAF6