TAPBP


Summary: This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TAP binding proteinMIM:601962Ensembl:ENSG00000231925HGNC:HGNC:11566PA363316p21.32

GO terms in TAPBP


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFTASGO:0015433peptide antigen-transporting ATPase activity
MFTASGO:0042288MHC class I protein binding
MFTASGO:0042605peptide antigen binding
MFIPIGO:0046978TAP1 binding
MFTASGO:0046978TAP1 binding
MFIPIGO:0046979TAP2 binding
MFTASGO:0046979TAP2 binding
MFTASGO:0051082unfolded protein binding
CCIDAGO:0000139Golgi membrane
CCTASGO:0005783endoplasmic reticulum
CCIDAGO:0005789endoplasmic reticulum membrane
CCTASGO:0016021integral component of membrane
CCTASGO:0030670phagocytic vesicle membrane
CCTASGO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane
CCNASGO:0042824MHC class I peptide loading complex
CCIDAGO:0042825TAP complex
CCTASGO:0071556integral component of lumenal side of endoplasmic reticulum membrane
BPTASGO:0002474antigen processing and presentation of peptide antigen via MHC class I
BPTASGO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
BPNASGO:0006890retrograde vesicle-mediated transport, Golgi to ER
BPTASGO:0006955immune response
BPIMPGO:0010468regulation of gene expression
BPIEAGO:0019885antigen processing and presentation of endogenous peptide antigen via MHC class I
BPIEAGO:0042886amide transport
BPISSGO:0050823peptide antigen stabilization
BPIDAGO:0061635regulation of protein complex stability
BPTASGO:0065003protein-containing complex assembly
BPTASGO:1990668vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane

Gene expression in normal tissue: TAPBP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TAPBP


DatabasePathway IDPathway Des.
kegghsa04612Antigen processing and presentation - Homo sapiens (human)
reactomeR-HSA-1236974ER-Phagosome pathway
reactomeR-HSA-1236975Antigen processing-Cross presentation
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
reactomeR-HSA-983170Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD748PHA-6657521

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TAPBP

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