TAPBP
Summary: This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TAP binding protein | MIM:601962 | Ensembl:ENSG00000231925 | HGNC:HGNC:11566 | PA36331 | 6p21.32 |
GO terms in TAPBP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015433 | peptide antigen-transporting ATPase activity |
| MF | TAS | GO:0042288 | MHC class I protein binding |
| MF | TAS | GO:0042605 | peptide antigen binding |
| MF | IPI | GO:0046978 | TAP1 binding |
| MF | TAS | GO:0046978 | TAP1 binding |
| MF | IPI | GO:0046979 | TAP2 binding |
| MF | TAS | GO:0046979 | TAP2 binding |
| MF | TAS | GO:0051082 | unfolded protein binding |
| CC | IDA | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0016021 | integral component of membrane |
| CC | TAS | GO:0030670 | phagocytic vesicle membrane |
| CC | TAS | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| CC | NAS | GO:0042824 | MHC class I peptide loading complex |
| CC | IDA | GO:0042825 | TAP complex |
| CC | TAS | GO:0071556 | integral component of lumenal side of endoplasmic reticulum membrane |
| BP | TAS | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I |
| BP | TAS | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| BP | NAS | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER |
| BP | TAS | GO:0006955 | immune response |
| BP | IMP | GO:0010468 | regulation of gene expression |
| BP | IEA | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| BP | IEA | GO:0042886 | amide transport |
| BP | ISS | GO:0050823 | peptide antigen stabilization |
| BP | IDA | GO:0061635 | regulation of protein complex stability |
| BP | TAS | GO:0065003 | protein-containing complex assembly |
| BP | TAS | GO:1990668 | vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane |
Gene expression in normal tissue: TAPBP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TAPBP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04612 | Antigen processing and presentation - Homo sapiens (human) |
| reactome | R-HSA-1236974 | ER-Phagosome pathway |
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| reactome | R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TAPBP
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