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TFF3

Summary: Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
trefoil factor 3	MIM:600633	Ensembl:ENSG00000160180	HGNC:HGNC:11757	PA36472	21q22.3

Gene Categories:

DRUGGABLE GENOME

GO terms in TFF3

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005576	extracellular region
CC	TAS	GO:0005576	extracellular region
CC	IBA	GO:0005615	extracellular space
CC	IEA	GO:0005737	cytoplasm
MF	ND	GO:0003674	molecular_function
MF	IPI	GO:0005515	protein binding

Gene expression in normal tissue: TFF3

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TFF3

Database	Pathway ID	Pathway Des.
pid	hif1_tfpathway	HIF-1-alpha transcription factor network
pid	il4_2pathway	IL4-mediated signaling events
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-8939211	ESR-mediated signaling
reactome	R-HSA-9006931	Signaling by Nuclear Receptors
reactome	R-HSA-9018519	Estrogen-dependent gene expression
biocarta	tffpathway	trefoil factors initiate mucosal healing

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD221	Tamoxifen	1
iGMDRD7	Aminoglutethimide	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TFF3

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.