THBS1


Summary: The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
thrombospondin 1MIM:188060Ensembl:ENSG00000137801HGNC:HGNC:11785PA3649715q14

GO terms in THBS1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0001786phosphatidylserine binding
MFIDAGO:0001968fibronectin binding
MFIMPGO:0005178integrin binding
MFNASGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFNASGO:0005515protein binding
MFIDAGO:0008201heparin binding
MFIDAGO:0017134fibroblast growth factor binding
MFIDAGO:0030169low-density lipoprotein particle binding
MFNASGO:0042802identical protein binding
MFIDAGO:0043236laminin binding
MFTASGO:0043394proteoglycan binding
MFISSGO:0050431transforming growth factor beta binding
MFTASGO:0050431transforming growth factor beta binding
MFIDAGO:0070051fibrinogen binding
MFIDAGO:0070052collagen V binding
BPIMPGO:0000187activation of MAPK activity
BPNASGO:0001666response to hypoxia
BPIDAGO:0001937negative regulation of endothelial cell proliferation
BPIMPGO:0001937negative regulation of endothelial cell proliferation
BPIDAGO:0001953negative regulation of cell-matrix adhesion
BPIMPGO:0002040sprouting angiogenesis
BPIEPGO:0002544chronic inflammatory response
BPTASGO:0002576platelet degranulation
BPIDAGO:0002581negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
BPIDAGO:0002605negative regulation of dendritic cell antigen processing and presentation
BPIDAGO:0006954inflammatory response
BPIEPGO:0006955immune response
BPIEAGO:0006986response to unfolded protein
BPIDAGO:0007050cell cycle arrest
BPNASGO:0007155cell adhesion
BPIDAGO:0008284positive regulation of cell proliferation
BPIEAGO:0009612response to mechanical stimulus
BPIDAGO:0009749response to glucose
BPIDAGO:0010595positive regulation of endothelial cell migration
BPIDAGO:0010596negative regulation of endothelial cell migration
BPIDAGO:0010748negative regulation of plasma membrane long-chain fatty acid transport
BPIDAGO:0010751negative regulation of nitric oxide mediated signal transduction
BPIDAGO:0010754negative regulation of cGMP-mediated signaling
BPIDAGO:0010757negative regulation of plasminogen activation
BPISSGO:0010759positive regulation of macrophage chemotaxis
BPIDAGO:0010763positive regulation of fibroblast migration
BPIDAGO:0016477cell migration
BPIDAGO:0016525negative regulation of angiogenesis
BPIMPGO:0016525negative regulation of angiogenesis
BPIDAGO:0018149peptide cross-linking
BPIDAGO:0030194positive regulation of blood coagulation
BPTASGO:0030198extracellular matrix organization
BPIDAGO:0030335positive regulation of cell migration
BPIMPGO:0030335positive regulation of cell migration
BPIDAGO:0030511positive regulation of transforming growth factor beta receptor signaling pathway
BPIDAGO:0032026response to magnesium ion
BPTASGO:0032570response to progesterone
BPIDAGO:0032695negative regulation of interleukin-12 production
BPISSGO:0032914positive regulation of transforming growth factor beta1 production
BPIEAGO:0033574response to testosterone
BPNASGO:0034605cellular response to heat
BPISSGO:0034976response to endoplasmic reticulum stress
BPIDAGO:0040037negative regulation of fibroblast growth factor receptor signaling pathway
BPIMPGO:0042327positive regulation of phosphorylation
BPIEPGO:0042493response to drug
BPIDAGO:0042535positive regulation of tumor necrosis factor biosynthetic process
BPIDAGO:0043032positive regulation of macrophage activation
BPIDAGO:0043066negative regulation of apoptotic process
BPIDAGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIDAGO:0043536positive regulation of blood vessel endothelial cell migration
BPIDAGO:0043537negative regulation of blood vessel endothelial cell migration
BPIDAGO:0043652engulfment of apoptotic cell
BPTASGO:0045652regulation of megakaryocyte differentiation
BPIDAGO:0045727positive regulation of translation
BPIMPGO:0045766positive regulation of angiogenesis
BPISSGO:0048266behavioral response to pain
BPIDAGO:0048661positive regulation of smooth muscle cell proliferation
BPIDAGO:0050921positive regulation of chemotaxis
BPIDAGO:0051592response to calcium ion
BPTASGO:0051895negative regulation of focal adhesion assembly
BPIDAGO:0051897positive regulation of protein kinase B signaling
BPIDAGO:0051918negative regulation of fibrinolysis
BPIEAGO:0071356cellular response to tumor necrosis factor
BPIEAGO:0071363cellular response to growth factor stimulus
BPIMPGO:0090051negative regulation of cell migration involved in sprouting angiogenesis
BPIDAGO:1902043positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
BPIMPGO:1903588negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
BPIGIGO:1903671negative regulation of sprouting angiogenesis
BPIDAGO:2000353positive regulation of endothelial cell apoptotic process
BPIDAGO:2000379positive regulation of reactive oxygen species metabolic process
BPIDAGO:2001027negative regulation of endothelial cell chemotaxis
BPTASGO:2001237negative regulation of extrinsic apoptotic signaling pathway
CCHDAGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIDAGO:0005577fibrinogen complex
CCHDAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCISSGO:0005783endoplasmic reticulum
CCTASGO:0005788endoplasmic reticulum lumen
CCIDAGO:0009897external side of plasma membrane
CCIDAGO:0009986cell surface
CCISSGO:0016529sarcoplasmic reticulum
CCIDAGO:0030141secretory granule
CCHDAGO:0031012extracellular matrix
CCIDAGO:0031012extracellular matrix
CCIDAGO:0031091platelet alpha granule
CCTASGO:0031093platelet alpha granule lumen
CCHDAGO:0062023collagen-containing extracellular matrix
CCHDAGO:0062023collagen-containing extracellular matrix
CCISSGO:0062023collagen-containing extracellular matrix
CCTASGO:0062023collagen-containing extracellular matrix
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: THBS1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in THBS1


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-216083Integrin cell surface interactions
reactomeR-HSA-3000170Syndecan interactions
reactomeR-HSA-3000171Non-integrin membrane-ECM interactions
reactomeR-HSA-3781865Diseases of glycosylation
reactomeR-HSA-3906995Diseases associated with O-glycosylation of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)
reactomeR-HSA-5173105O-linked glycosylation
reactomeR-HSA-5173214O-glycosylation of TSR domain-containing proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2006miR-targeted genes in squamous cell - TarBase
wikipathwaysWP2806Human Complement System
wikipathwaysWP2828Bladder Cancer
wikipathwaysWP2864Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathwaysWP2911miRNA targets in ECM and membrane receptors
wikipathwaysWP306Focal Adhesion
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4132RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP453Inflammatory Response Pathway
wikipathwaysWP560TGF-beta Receptor Signaling
wikipathwaysWP615Senescence and Autophagy in Cancer
pidintegrin1_pathwayBeta1 integrin cell surface interactions
pidintegrin3_pathwayBeta3 integrin cell surface interactions
pidintegrin_a4b1_pathwayAlpha4 beta1 integrin signaling events
pidsyndecan_4_pathwaySyndecan-4-mediated signaling events
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04145Phagosome - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04512ECM-receptor interaction - Homo sapiens (human)
kegghsa05144Malaria - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD134Sorafenib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in THBS1

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