TIGIT
Summary: This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
T cell immunoreceptor with Ig and ITIM domains | MIM:612859 | Ensembl:ENSG00000181847 | HGNC:HGNC:26838 | PA164726482 | 3q13.31 |
Gene Categories:
CELL SURFACEGO terms in TIGIT
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IMP | GO:0032695 | negative regulation of interleukin-12 production |
BP | IMP | GO:0032733 | positive regulation of interleukin-10 production |
BP | IDA | GO:0050868 | negative regulation of T cell activation |
BP | IMP | GO:0050868 | negative regulation of T cell activation |
CC | IDA | GO:0009986 | cell surface |
MF | IPI | GO:0005102 | signaling receptor binding |
MF | IPI | GO:0005515 | protein binding |
MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: TIGIT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TIGIT
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TIGIT