TMOD2


Summary: This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tropomodulin 2MIM:602928Ensembl:ENSG00000128872HGNC:HGNC:11872PA3657315q21.2

GO terms in TMOD2


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003779actin binding
MFIBAGO:0005523tropomyosin binding
CCIBAGO:0005856cytoskeleton
CCIBAGO:0005865striated muscle thin filament
CCIBAGO:0030016myofibril
CCIEAGO:0030426growth cone
BPIBAGO:0006936muscle contraction
BPIBAGO:0007015actin filament organization
BPIEAGO:0007270neuron-neuron synaptic transmission
BPTASGO:0007399nervous system development
BPIEAGO:0007611learning or memory
BPIBAGO:0030239myofibril assembly
BPIEAGO:0045745positive regulation of G-protein coupled receptor protein signaling pathway
BPIEAGO:0051694pointed-end actin filament capping

Gene expression in normal tissue: TMOD2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TMOD2


DatabasePathway IDPathway Des.
reactomeR-HSA-390522Striated Muscle Contraction
reactomeR-HSA-397014Muscle contraction

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD491TAE-6841
iGMDRD30917AAG2
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TMOD2

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