TMOD2
Summary: This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
tropomodulin 2 | MIM:602928 | Ensembl:ENSG00000128872 | HGNC:HGNC:11872 | PA36573 | 15q21.2 |
GO terms in TMOD2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0003779 | actin binding |
MF | IBA | GO:0005523 | tropomyosin binding |
CC | IBA | GO:0005856 | cytoskeleton |
CC | IBA | GO:0005865 | striated muscle thin filament |
CC | IBA | GO:0030016 | myofibril |
CC | IEA | GO:0030426 | growth cone |
BP | IBA | GO:0006936 | muscle contraction |
BP | IBA | GO:0007015 | actin filament organization |
BP | IEA | GO:0007270 | neuron-neuron synaptic transmission |
BP | TAS | GO:0007399 | nervous system development |
BP | IEA | GO:0007611 | learning or memory |
BP | IBA | GO:0030239 | myofibril assembly |
BP | IEA | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway |
BP | IEA | GO:0051694 | pointed-end actin filament capping |
Gene expression in normal tissue: TMOD2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TMOD2
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-390522 | Striated Muscle Contraction |
reactome | R-HSA-397014 | Muscle contraction |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TMOD2