Summary: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012].

transmembrane serine protease 3MIM:605511Ensembl:ENSG00000160183HGNC:HGNC:11877PA3657821q22.3

GO terms in TMPRSS3

Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0006883cellular sodium ion homeostasis
BPIDAGO:0006883cellular sodium ion homeostasis
BPIEAGO:0006898receptor-mediated endocytosis
BPIBAGO:0007605sensory perception of sound
BPIEAGO:0007605sensory perception of sound
CCHDAGO:0005783endoplasmic reticulum
CCIBAGO:0005783endoplasmic reticulum
CCIBAGO:0005789endoplasmic reticulum membrane
CCIDAGO:0005789endoplasmic reticulum membrane
CCNASGO:0016021integral component of membrane
CCIEAGO:0043025neuronal cell body
MFNASGO:0004252serine-type endopeptidase activity
MFIEAGO:0005044scavenger receptor activity
MFIBAGO:0017080sodium channel regulator activity
MFIDAGO:0017080sodium channel regulator activity

Gene expression in normal tissue: TMPRSS3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TMPRSS3

DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TMPRSS3