Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012].

TNF receptor superfamily member 11aMIM:603499Ensembl:ENSG00000141655HGNC:HGNC:11908PA3660118q21.33

GO terms in TNFRSF11A

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004888transmembrane signaling receptor activity
MFISSGO:0005031tumor necrosis factor-activated receptor activity
MFIPIGO:0005515protein binding
MFIPIGO:0019955cytokine binding
MFTASGO:0038023signaling receptor activity
MFIEAGO:0046872metal ion binding
BPIMPGO:0002250adaptive immune response
BPNASGO:0002548monocyte chemotaxis
BPTASGO:0007165signal transduction
BPTASGO:0007267cell-cell signaling
BPTASGO:0008284positive regulation of cell proliferation
BPIEAGO:0009314response to radiation
BPIMPGO:0030316osteoclast differentiation
BPISSGO:0032496response to lipopolysaccharide
BPISSGO:0033209tumor necrosis factor-mediated signaling pathway
BPTASGO:0033209tumor necrosis factor-mediated signaling pathway
BPIMPGO:0034097response to cytokine
BPISSGO:0034612response to tumor necrosis factor
BPIMPGO:0043507positive regulation of JUN kinase activity
BPIEAGO:0045780positive regulation of bone resorption
BPIEAGO:0048535lymph node development
BPIDAGO:0051091positive regulation of DNA-binding transcription factor activity
BPISSGO:0051091positive regulation of DNA-binding transcription factor activity
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIMPGO:0051092positive regulation of NF-kappaB transcription factor activity
BPISSGO:0060086circadian temperature homeostasis
BPIEAGO:0060749mammary gland alveolus development
BPISSGO:0070555response to interleukin-1
BPISSGO:0071812positive regulation of fever generation by positive regulation of prostaglandin secretion
BPIMPGO:0071847TNFSF11-mediated signaling pathway
BPIMPGO:0071848positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
BPIEAGO:0072674multinuclear osteoclast differentiation
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0009897external side of plasma membrane

Gene expression in normal tissue: TNFRSF11A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNFRSF11A

DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5676594TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
biocartaranklpathwaybone remodeling
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
wikipathwaysWP12Osteoclast Signaling
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNFRSF11A