TPGS2
Summary: This gene encodes a protein that is a component of the neuronal polyglutamylase complex, which plays a role in post-translational addition of glutamate residues to C-terminal tubulin tails. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
tubulin polyglutamylase complex subunit 2 | Ensembl:ENSG00000134779 | HGNC:HGNC:24561 | PA128394637 | 18q12.2 |
GO terms in TPGS2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IEA | GO:0005737 | cytoplasm |
CC | IEA | GO:0005874 | microtubule |
Gene expression in normal tissue: TPGS2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TPGS2
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-597592 | Post-translational protein modification |
reactome | R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin |
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in TPGS2