TSPYL2


Summary: This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TSPY like 2MIM:300564Ensembl:ENSG00000184205HGNC:HGNC:24358PA134930188Xp11.22

Gene Categories:

KINASETUMOR SUPPRESSOR

GO terms in TSPYL2


Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0000182rDNA binding
MFIPIGO:0005515protein binding
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIEAGO:0005737cytoplasm
BPIEAGO:0006334nucleosome assembly
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0007049cell cycle
BPIDAGO:0008156negative regulation of DNA replication
BPNASGO:0009966regulation of signal transduction
BPIDAGO:0030308negative regulation of cell growth
BPTASGO:0036498IRE1-mediated unfolded protein response
BPNASGO:0045786negative regulation of cell cycle
BPIDAGO:0045859regulation of protein kinase activity

Gene expression in normal tissue: TSPYL2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TSPYL2


DatabasePathway IDPathway Des.
reactomeR-HSA-381038XBP1(S) activates chaperone genes
reactomeR-HSA-381070IRE1alpha activates chaperones
reactomeR-HSA-381119Unfolded Protein Response (UPR)
reactomeR-HSA-392499Metabolism of proteins
wikipathwaysWP3472XBP1(S) activates chaperone genes

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012
iGMDRD399Selumetinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TSPYL2

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