UBA2
Summary: Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ubiquitin like modifier activating enzyme 2 | MIM:613295 | Ensembl:ENSG00000126261 | HGNC:HGNC:30661 | PA162407583 | 19q13.11 |
GO terms in UBA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0016925 | protein sumoylation |
| BP | IDA | GO:0016925 | protein sumoylation |
| BP | IEA | GO:0016925 | protein sumoylation |
| BP | IMP | GO:0016925 | protein sumoylation |
| BP | TAS | GO:0016925 | protein sumoylation |
| BP | IEA | GO:0043085 | positive regulation of catalytic activity |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0031510 | SUMO activating enzyme complex |
| MF | IMP | GO:0000287 | magnesium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IMP | GO:0005524 | ATP binding |
| MF | TAS | GO:0008047 | enzyme activator activity |
| MF | IEA | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0016740 | transferase activity |
| MF | IEA | GO:0016881 | acid-amino acid ligase activity |
| MF | IBA | GO:0019948 | SUMO activating enzyme activity |
| MF | IDA | GO:0019948 | SUMO activating enzyme activity |
| MF | TAS | GO:0019948 | SUMO activating enzyme activity |
| MF | IPI | GO:0032183 | SUMO binding |
| MF | IPI | GO:0044388 | small protein activating enzyme binding |
| MF | IPI | GO:0044390 | ubiquitin-like protein conjugating enzyme binding |
| MF | IMP | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: UBA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UBA2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3065676 | SUMO is conjugated to E1 (UBA2:SAE1) |
| reactome | R-HSA-3065676 | SUMO is conjugated to E1 (UBA2:SAE1) |
| reactome | R-HSA-3065678 | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
| reactome | R-HSA-3065678 | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
| reactome | R-HSA-3215018 | Processing and activation of SUMO |
| reactome | R-HSA-3215018 | Processing and activation of SUMO |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-597592 | Post-translational protein modification |
| biocarta | sumopathway | basic mechanisms of sumoylation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UBA2
CLASSFICATION
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