UBA2


Summary: Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ubiquitin like modifier activating enzyme 2MIM:613295Ensembl:ENSG00000126261HGNC:HGNC:30661PA16240758319q13.11

GO terms in UBA2


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0016925protein sumoylation
BPIDAGO:0016925protein sumoylation
BPIEAGO:0016925protein sumoylation
BPIMPGO:0016925protein sumoylation
BPTASGO:0016925protein sumoylation
BPIEAGO:0043085positive regulation of catalytic activity
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0031510SUMO activating enzyme complex
MFIMPGO:0000287magnesium ion binding
MFIPIGO:0005515protein binding
MFIMPGO:0005524ATP binding
MFTASGO:0008047enzyme activator activity
MFIEAGO:0008134transcription factor binding
MFIEAGO:0016740transferase activity
MFIEAGO:0016881acid-amino acid ligase activity
MFIBAGO:0019948SUMO activating enzyme activity
MFIDAGO:0019948SUMO activating enzyme activity
MFTASGO:0019948SUMO activating enzyme activity
MFIPIGO:0032183SUMO binding
MFIPIGO:0044388small protein activating enzyme binding
MFIPIGO:0044390ubiquitin-like protein conjugating enzyme binding
MFIMPGO:0046982protein heterodimerization activity
MFIPIGO:0046982protein heterodimerization activity

Gene expression in normal tissue: UBA2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UBA2


DatabasePathway IDPathway Des.
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3065676SUMO is conjugated to E1 (UBA2:SAE1)
reactomeR-HSA-3065676SUMO is conjugated to E1 (UBA2:SAE1)
reactomeR-HSA-3065678SUMO is transferred from E1 to E2 (UBE2I, UBC9)
reactomeR-HSA-3065678SUMO is transferred from E1 to E2 (UBE2I, UBC9)
reactomeR-HSA-3215018Processing and activation of SUMO
reactomeR-HSA-3215018Processing and activation of SUMO
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-597592Post-translational protein modification
biocartasumopathwaybasic mechanisms of sumoylation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD748PHA-6657521

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UBA2

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