UNC80


Summary: The protein encoded by this gene is a component of a voltage-independent 'leak' ion-channel complex, in which it performs essential functions, such as serving as a bridge between two other components (sodium leak channel non-selective and UNC79) and as a scaffold for Src kinases. Leak channels play an importnat role in establishment and maintenance of resting membrane potentials in neurons. Mutations in this gene are associated with congenital infantile encephalopathy, intellectual disability and growth issues. [provided by RefSeq, Aug 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
unc-80 homolog, NALCN channel complex subunitMIM:612636Ensembl:ENSG00000144406HGNC:HGNC:26582PA1656977052q34

GO terms in UNC80


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0034220ion transmembrane transport
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane

Gene expression in normal tissue: UNC80

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UNC80


DatabasePathway IDPathway Des.
reactomeR-HSA-2672351Stimuli-sensing channels
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD536PLX-47201

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UNC80

​​​​