UPK1B


Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
uroplakin 1BMIM:602380Ensembl:ENSG00000114638HGNC:HGNC:12578PA372103q13.32

GO terms in UPK1B


Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0005198structural molecule activity
BPIBAGO:0007166cell surface receptor signaling pathway
BPIDAGO:0030855epithelial cell differentiation
CCIBAGO:0005887integral component of plasma membrane
CCNASGO:0016021integral component of membrane
CCIEAGO:0016324apical plasma membrane
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: UPK1B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UPK1B


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD536PLX-47201

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UPK1B

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