UST
Summary: Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| uronyl 2-sulfotransferase | MIM:610752 | Ensembl:ENSG00000111962 | HGNC:HGNC:17223 | PA38213 | 6q25.1 |
GO terms in UST
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | TAS | GO:0006477 | protein sulfation |
| BP | IEA | GO:0030010 | establishment of cell polarity |
| BP | TAS | GO:0030208 | dermatan sulfate biosynthetic process |
| BP | IEA | GO:0050770 | regulation of axonogenesis |
| MF | IBA | GO:0008146 | sulfotransferase activity |
| MF | TAS | GO:0008146 | sulfotransferase activity |
Gene expression in normal tissue: UST
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UST
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | PWY-6567 | chondroitin sulfate biosynthesis (late stages) |
| humancyc | PWY-6568 | dermatan sulfate biosynthesis (late stages) |
| humancyc | PWY-6569 | chondroitin sulfate biosynthesis |
| humancyc | PWY-6571 | dermatan sulfate biosynthesis |
| kegg | hsa00532 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
| reactome | R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism |
| reactome | R-HSA-2022923 | Dermatan sulfate biosynthesis |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UST
CLASSFICATION
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