VAMP4


Summary: Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
vesicle associated membrane protein 4MIM:606909Ensembl:ENSG00000117533HGNC:HGNC:12645PA372691q24.3

Gene Categories:

CELL SURFACE

GO terms in VAMP4


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0000139Golgi membrane
CCTASGO:0005764lysosome
CCTASGO:0005768endosome
CCIDAGO:0005794Golgi apparatus
CCTASGO:0005886plasma membrane
CCIDAGO:0009986cell surface
CCTASGO:0030133transport vesicle
CCIEAGO:0030285integral component of synaptic vesicle membrane
CCTASGO:0030665clathrin-coated vesicle membrane
CCTASGO:0032588trans-Golgi network membrane
BPIMPGO:0000226microtubule cytoskeleton organization
BPIMPGO:0006888ER to Golgi vesicle-mediated transport
BPIDAGO:0035493SNARE complex assembly
BPIMPGO:0043001Golgi to plasma membrane protein transport
BPTASGO:0061024membrane organization
BPIMPGO:0090161Golgi ribbon formation
MFIPIGO:0005515protein binding

Gene expression in normal tissue: VAMP4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in VAMP4


DatabasePathway IDPathway Des.
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-6811440Retrograde transport at the Trans-Golgi-Network
reactomeR-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER traffic
reactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
reactomeR-HSA-8856828Clathrin-mediated endocytosis
kegghsa04130SNARE interactions in vesicular transport - Homo sapiens (human)
pharmgkbPA162355621Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD409Saracatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in VAMP4

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