VTCN1
Summary: This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| V-set domain containing T cell activation inhibitor 1 | MIM:608162 | Ensembl:ENSG00000134258 | HGNC:HGNC:28873 | PA142670611 | 1p13.1-p12 |
GO terms in VTCN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IEA | GO:0005102 | signaling receptor binding |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0009897 | external side of plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | IEA | GO:0001562 | response to protozoan |
| BP | IBA | GO:0001817 | regulation of cytokine production |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | IEA | GO:0042102 | positive regulation of T cell proliferation |
| BP | IMP | GO:0042130 | negative regulation of T cell proliferation |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0050776 | regulation of immune response |
| BP | IBA | GO:0050852 | T cell receptor signaling pathway |
| BP | IMP | GO:0050868 | negative regulation of T cell activation |
| BP | IEA | GO:0072602 | interleukin-4 secretion |
| BP | IEA | GO:0072643 | interferon-gamma secretion |
| BP | IEA | GO:1900042 | positive regulation of interleukin-2 secretion |
Gene expression in normal tissue: VTCN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in VTCN1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in VTCN1
CLASSFICATION
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