XRCC1
Summary: The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
X-ray repair cross complementing 1 | MIM:194360 | Ensembl:ENSG00000073050 | HGNC:HGNC:12828 | PA369 | 19q13.31 |
GO terms in XRCC1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | TAS | GO:0003909 | DNA ligase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IPI | GO:0019899 | enzyme binding |
MF | IMP | GO:0032356 | oxidized DNA binding |
MF | IEA | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity |
CC | IEA | GO:0000784 | nuclear chromosome, telomeric region |
CC | IDA | GO:0000790 | nuclear chromatin |
CC | IBA | GO:0005634 | nucleus |
CC | IDA | GO:0005634 | nucleus |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IDA | GO:0005730 | nucleolus |
CC | IEA | GO:0070522 | ERCC4-ERCC1 complex |
BP | IEA | GO:0000012 | single strand break repair |
BP | TAS | GO:0000724 | double-strand break repair via homologous recombination |
BP | IEA | GO:0001666 | response to hypoxia |
BP | TAS | GO:0006283 | transcription-coupled nucleotide-excision repair |
BP | IBA | GO:0006284 | base-excision repair |
BP | TAS | GO:0006288 | base-excision repair, DNA ligation |
BP | TAS | GO:0006297 | nucleotide-excision repair, DNA gap filling |
BP | IEA | GO:0006303 | double-strand break repair via nonhomologous end joining |
BP | IEA | GO:0010033 | response to organic substance |
BP | IMP | GO:0010836 | negative regulation of protein ADP-ribosylation |
BP | IEA | GO:0021587 | cerebellum morphogenesis |
BP | IEA | GO:0021766 | hippocampus development |
BP | IDA | GO:0033194 | response to hydroperoxide |
BP | IEA | GO:0042493 | response to drug |
BP | IMP | GO:0050882 | voluntary musculoskeletal movement |
BP | IEA | GO:0061819 | telomeric DNA-containing double minutes formation |
BP | IGI | GO:1903518 | positive regulation of single strand break repair |
BP | IMP | GO:1903518 | positive regulation of single strand break repair |
BP | IMP | GO:1904877 | positive regulation of DNA ligase activity |
BP | IEA | GO:1905765 | negative regulation of protection from non-homologous end joining at telomere |
BP | IMP | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange |
Gene expression in normal tissue: XRCC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in XRCC1
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway |
reactome | R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway |
reactome | R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) |
reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
reactome | R-HSA-5693538 | Homology Directed Repair |
reactome | R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER |
reactome | R-HSA-5696398 | Nucleotide Excision Repair |
reactome | R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) |
reactome | R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
reactome | R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER |
reactome | R-HSA-73884 | Base Excision Repair |
reactome | R-HSA-73894 | DNA Repair |
reactome | R-HSA-73933 | Resolution of Abasic Sites (AP sites) |
kegg | hsa03410 | Base excision repair - Homo sapiens (human) |
pid | e2f_pathway | E2F transcription factor network |
pid | foxm1pathway | FOXM1 transcription factor network |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD79 | Gemcitabine | 1 |
iGMDRD441 | TW 37 | 1 |
iGMDRD160 | Cis-Platin | 1 |
iGMDRD288 | Carboplatin | 1 |
iGMDRD117 | Docetaxel | 1 |
iGMDRD281 | Vinorelbine base | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in XRCC1