XRCC1


Summary: The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
X-ray repair cross complementing 1MIM:194360Ensembl:ENSG00000073050HGNC:HGNC:12828PA36919q13.31

Gene Categories:

DRUG RESISTANCEDNA REPAIR

GO terms in XRCC1


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003909DNA ligase activity
MFIPIGO:0005515protein binding
MFIPIGO:0019899enzyme binding
MFIMPGO:0032356oxidized DNA binding
MFIEAGO:19905993' overhang single-stranded DNA endodeoxyribonuclease activity
CCIEAGO:0000784nuclear chromosome, telomeric region
CCIDAGO:0000790nuclear chromatin
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIEAGO:0070522ERCC4-ERCC1 complex
BPIEAGO:0000012single strand break repair
BPTASGO:0000724double-strand break repair via homologous recombination
BPIEAGO:0001666response to hypoxia
BPTASGO:0006283transcription-coupled nucleotide-excision repair
BPIBAGO:0006284base-excision repair
BPTASGO:0006288base-excision repair, DNA ligation
BPTASGO:0006297nucleotide-excision repair, DNA gap filling
BPIEAGO:0006303double-strand break repair via nonhomologous end joining
BPIEAGO:0010033response to organic substance
BPIMPGO:0010836negative regulation of protein ADP-ribosylation
BPIEAGO:0021587cerebellum morphogenesis
BPIEAGO:0021766hippocampus development
BPIDAGO:0033194response to hydroperoxide
BPIEAGO:0042493response to drug
BPIMPGO:0050882voluntary musculoskeletal movement
BPIEAGO:0061819telomeric DNA-containing double minutes formation
BPIGIGO:1903518positive regulation of single strand break repair
BPIMPGO:1903518positive regulation of single strand break repair
BPIMPGO:1904877positive regulation of DNA ligase activity
BPIEAGO:1905765negative regulation of protection from non-homologous end joining at telomere
BPIMPGO:1990414replication-born double-strand break repair via sister chromatid exchange

Gene expression in normal tissue: XRCC1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in XRCC1


DatabasePathway IDPathway Des.
reactomeR-HSA-110381Resolution of AP sites via the single-nucleotide replacement pathway
reactomeR-HSA-5649702APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
reactomeR-HSA-5685939HDR through MMEJ (alt-NHEJ)
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5696397Gap-filling DNA repair synthesis and ligation in GG-NER
reactomeR-HSA-5696398Nucleotide Excision Repair
reactomeR-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)
reactomeR-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)
reactomeR-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NER
reactomeR-HSA-73884Base Excision Repair
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-73933Resolution of Abasic Sites (AP sites)
kegghsa03410Base excision repair - Homo sapiens (human)
pide2f_pathwayE2F transcription factor network
pidfoxm1pathwayFOXM1 transcription factor network

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD79Gemcitabine1
iGMDRD441TW 371
iGMDRD160Cis-Platin1
iGMDRD288Carboplatin1
iGMDRD117Docetaxel1
iGMDRD281Vinorelbine base1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in XRCC1

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