XRCC5


Summary: The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
X-ray repair cross complementing 5MIM:194364Ensembl:ENSG00000079246HGNC:HGNC:12833PA374252q35

GO terms in XRCC5


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0000783nuclear telomere cap complex
CCHDAGO:0000784nuclear chromosome, telomeric region
CCIBAGO:0000784nuclear chromosome, telomeric region
CCIDAGO:0000784nuclear chromosome, telomeric region
CCTASGO:0005576extracellular region
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0005730nucleolus
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCHDAGO:0016020membrane
CCIDAGO:0032991protein-containing complex
CCIDAGO:0032993protein-DNA complex
CCTASGO:0034774secretory granule lumen
CCIBAGO:0043564Ku70:Ku80 complex
CCIDAGO:0043564Ku70:Ku80 complex
CCTASGO:0043564Ku70:Ku80 complex
CCIDAGO:0070419nonhomologous end joining complex
CCIDAGO:1990904ribonucleoprotein complex
BPIBAGO:0000723telomere maintenance
BPIEAGO:0000723telomere maintenance
BPIDAGO:0002218activation of innate immune response
BPIMPGO:0006302double-strand break repair
BPIBAGO:0006303double-strand break repair via nonhomologous end joining
BPIDAGO:0006303double-strand break repair via nonhomologous end joining
BPIMPGO:0006303double-strand break repair via nonhomologous end joining
BPTASGO:0006303double-strand break repair via nonhomologous end joining
BPIEAGO:0006310DNA recombination
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0007420brain development
BPIEAGO:0008283cell proliferation
BPTASGO:0032204regulation of telomere maintenance
BPIMPGO:0032212positive regulation of telomere maintenance via telomerase
BPTASGO:0032481positive regulation of type I interferon production
BPIEAGO:0032508DNA duplex unwinding
BPIEAGO:0042493response to drug
BPTASGO:0043085positive regulation of catalytic activity
BPTASGO:0043312neutrophil degranulation
BPIEAGO:0045087innate immune response
BPIDAGO:0045860positive regulation of protein kinase activity
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0048660regulation of smooth muscle cell proliferation
BPIEAGO:0050769positive regulation of neurogenesis
BPTASGO:0051973positive regulation of telomerase activity
BPIEAGO:0060218hematopoietic stem cell differentiation
BPTASGO:0070198protein localization to chromosome, telomeric region
BPIEAGO:0071398cellular response to fatty acid
BPIEAGO:0071475cellular hyperosmotic salinity response
BPIBAGO:0071480cellular response to gamma radiation
BPIDAGO:0071480cellular response to gamma radiation
BPIBAGO:0071481cellular response to X-ray
BPIEAGO:0071481cellular response to X-ray
BPTASGO:0075713establishment of integrated proviral latency
BPIMPGO:1904430negative regulation of t-circle formation
BPIEAGO:1990830cellular response to leukemia inhibitory factor
MFNASGO:0003677DNA binding
MFIEAGO:0003684damaged DNA binding
MFIBAGO:0003690double-stranded DNA binding
MFTASGO:0003690double-stranded DNA binding
MFIDAGO:0003691double-stranded telomeric DNA binding
MFHDAGO:0003723RNA binding
MFIDAGO:0003723RNA binding
MFIEAGO:0004003ATP-dependent DNA helicase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0008022protein C-terminus binding
MFTASGO:0008047enzyme activator activity
MFIPIGO:0031625ubiquitin protein ligase binding
MFIBAGO:0042162telomeric DNA binding
MFIDAGO:0042162telomeric DNA binding
MFTASGO:0042162telomeric DNA binding
MFIDAGO:0044212transcription regulatory region DNA binding
MFIPIGO:0044877protein-containing complex binding
MFIMPGO:00515755'-deoxyribose-5-phosphate lyase activity

Gene expression in normal tissue: XRCC5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in XRCC5


DatabasePathway IDPathway Des.
reactomeR-HSA-162587HIV Life Cycle
reactomeR-HSA-162592Integration of provirus
reactomeR-HSA-162594Early Phase of HIV Life Cycle
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-1643685Disease
reactomeR-HSA-1648432-LTR circle formation
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-1834941STING mediated induction of host immune responses
reactomeR-HSA-1834949Cytosolic sensors of pathogen-associated DNA
reactomeR-HSA-3270619IRF3-mediated induction of type I IFN
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693571Nonhomologous End-Joining (NHEJ)
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-73894DNA Repair
biocartatelpathwaytelomeres telomerase cellular aging and immortality
netpathPathway_AndrogenReceptorAndrogenReceptor
pidar_pathwayCoregulation of Androgen receptor activity
pidbard1pathwayBARD1 signaling events
piddnapk_pathwayDNA-PK pathway in nonhomologous end joining
pidtelomerasepathwayRegulation of Telomerase
kegghsa03450Non-homologous end-joining - Homo sapiens (human)
wikipathwaysWP438Non-homologous end joining

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD372TGX 2211

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in XRCC5

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