ZMAT3


Summary: This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
zinc finger matrin-type 3MIM:606452Ensembl:ENSG00000172667HGNC:HGNC:29983PA1451475603q26.32

GO terms in ZMAT3


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006974cellular response to DNA damage stimulus
BPIEAGO:0015031protein transport
BPIEAGO:0040008regulation of growth
BPIEAGO:0043065positive regulation of apoptotic process
CCIDAGO:0005654nucleoplasm
CCIEAGO:0005730nucleolus
CCIDAGO:0005886plasma membrane
MFHDAGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding

Gene expression in normal tissue: ZMAT3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ZMAT3


DatabasePathway IDPathway Des.
wikipathwaysWP3982miRNA regulation of p53 pathway in prostate cancer
kegghsa04115p53 signaling pathway - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD512nutlin 31

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ZMAT3

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