ZNF81


Summary: This gene encodes a protein that likely functions as a transcription factor. The protein contains an N-terminal KRAB domain and several C2H2-type zinc finger motifs. Mutations in this gene cause an X-linked form of intellectual disability (MRX45). Microduplication of a region of chromosome X including this gene has also been associated with other forms of intellectual disability. [provided by RefSeq, Jul 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
zinc finger protein 81MIM:314998Ensembl:ENSG00000197779HGNC:HGNC:13156PA37730Xp11.23

GO terms in ZNF81


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005634nucleus
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006357regulation of transcription by RNA polymerase II
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0003677DNA binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: ZNF81

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ZNF81


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD190Nilotinib2
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ZNF81

​​​​