iGMDRD181

Canonical SMILES: CC1=CC=C(C=C1)NC2=CC(=O)C3=C(C2=O)N=C(S3)C

InChI: InChI=1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3

InChI Key: HFPLHASLIOXVGS-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameCDK4 inhibitor
CHEMBLCHEMBL290904
Pubchem CID481747
Drug StatusFamily
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

SOFT_TISSUtissue: SOFT_TISSU cancer: SOFT_TISSUE model num: 0SOFT_TISSUEtissue: SOFT_TISSUE cancer: Liposarcoma (LIPO) model num: 1LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Lung Cancer model num: 1BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: Acute Lymphoid Leukemia (ALL) model num: 3

Drug-gene pathway enrichments

5reactome: RNA Polymerase II Transcription5reactome: Generic Transcription Pathway5reactome: Signal Transduction5reactome: Gene expression (Transcription)4reactome: Cell Cycle4kegg: Pathways in cancer - Homo sapiens (human)4reactome: Cell Cycle, Mitotic4kegg: Human papillomavirus infection - Homo sapiens (human)4kegg: Breast cancer - Homo sapiens (human)3wikipathways: Signaling Pathways in Glioblastoma

Drug-gene GO enrichments

7CC: nucleus4CC: cytosol4MF: cyclin-dependent protein serine/threonine kinase activity4BP: positive regulation of cell proliferation4MF: protein binding4BP: aortic valve morphogenesis4CC: nucleoplasm3CC: chromatin3BP: Notch signaling pathway3BP: negative regulation of transcription, DNA-templated

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3845 KRAS 1
4851 NOTCH1 3
1019 CDK4 1
5925 RB1 1
Showing 1 to 4 of 4 rows

Gene in drug-gene network: Network Plot

Models in CDK4 inhibitor

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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