iGMDRD189

Canonical SMILES: C1=CC(=CC(=C1)Cl)NC2=NC=CC(=N2)C3=CC(=NC=C3)NCCCO

InChI: InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(12-14)23-18-22-9-6-16(24-18)13-5-8-21-17(11-13)20-7-2-10-25/h1,3-6,8-9,11-12,25H,2,7,10H2,(H,20,21)(H,22,23,24)

InChI Key: IYNDTACKOAXKBJ-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameCGP 60474
CHEMBLCHEMBL300389
Pubchem CID644215
Drug StatusAlone
Drug TypeSmall Molecule


Drug Pathways:

Cell cycle

Drug-model tissue-cancer distribution: Bubble Plot

BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 3undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 9LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 1BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1

Drug-gene pathway enrichments

8reactome: Signal Transduction6reactome: Signaling by Receptor Tyrosine Kinases5reactome: Immune System4reactome: Intracellular signaling by second messengers4reactome: Signaling by ERBB24kegg: Proteoglycans in cancer - Homo sapiens (human)4reactome: PIP3 activates AKT signaling3kegg: PI3K-Akt signaling pathway - Homo sapiens (human)3reactome: DAP12 signaling3reactome: Gene expression (Transcription)

Drug-gene GO enrichments

9MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding8MF: protein tyrosine kinase activity6BP: positive regulation of transcription by RNA polymerase II5BP: negative regulation of transcription, DNA-templated5BP: positive regulation of gene expression5MF: protein binding5CC: nucleus4MF: identical protein binding4MF: protein heterodimerization activity4CC: plasma membrane

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3932 LCK 1
7157 TP53 1
162979 ZNF296 2
7291 TWIST1 1
Showing 1 to 4 of 6 rows

Gene in drug-gene network: Network Plot

Models in CGP 60474

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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