iGMDRD688

Canonical SMILES: CC(C1=C2C(=CC(=C1)C(=O)N(C)C)C(=O)C=C(O2)N3CCOCC3)NC4=CC(=CC(=C4)F)F

InChI: InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14-/m1/s1

InChI Key: LMJFJIDLEAWOQJ-CQSZACIVSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameAZD8186
Pubchem CID52913800
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1PANCREAtissue: PANCREA cancer: PANCREAS model num: 0PANCREAStissue: PANCREAS cancer: Pancreatic Adenocarcinoma (PAAD) model num: 1PROSTATtissue: PROSTAT cancer: PROSTATE model num: 0PROSTATEtissue: PROSTATE cancer: Prostate Cancer model num: 1BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: Acute Lymphoid Leukemia (ALL) model num: 7

Drug-gene pathway enrichments

3reactome: Signal Transduction2wikipathways: PI3K-AKT-mTOR signaling pathway and therapeutic opportunities2pid: PDGFR-beta signaling pathway2kegg: Central carbon metabolism in cancer - Homo sapiens (human)2wikipathways: Focal Adhesion-PI3K-Akt-mTOR-signaling pathway2pid: Class I PI3K signaling events2reactome: Signaling by ERBB22reactome: Adaptive Immune System2wikipathways: PI3K-Akt Signaling Pathway2kegg: Prostate cancer - Homo sapiens (human)

Drug-gene GO enrichments

3CC: cytosol3CC: cytoplasm2CC: plasma membrane2CC: nucleoplasm2CC: mitochondrion2MF: protein binding2BP: protein dephosphorylation2BP: phosphatidylinositol dephosphorylation2BP: negative regulation of protein kinase B signaling2BP: negative regulation of phosphatidylinositol 3-kinase signaling

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3845 KRAS 1
5728 PTEN 9
Showing 1 to 2 of 2 rows

Gene in drug-gene network: Network Plot

Models in AZD8186

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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