iGMDRD722

Canonical SMILES: CC1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=N)(=O)C)C4=C5C=CNC5=NC=C4

InChI: InChI=1S/C20H24N6O2S/c1-13-12-28-10-9-26(13)17-11-16(20(5-6-20)29(2,21)27)24-19(25-17)15-4-8-23-18-14(15)3-7-22-18/h3-4,7-8,11,13,21H,5-6,9-10,12H2,1-2H3,(H,22,23)/t13-,29-/m1/s1

InChI Key: OHUHVTCQTUDPIJ-JYCIKRDWSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameAZD6738
Pubchem CID54761300
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: B-Cell Lymphoma (BCL) model num: 6

Drug-gene pathway enrichments

3reactome: G1/S DNA Damage Checkpoints3reactome: Cell Cycle3reactome: Cell Cycle Checkpoints2biocarta: regulation of cell cycle progression by plk32biocarta: hypoxia and p53 in the cardiovascular system2biocarta: cell cycle: g2/m checkpoint2biocarta: rb tumor suppressor/checkpoint signaling in response to dna damage2pid: p53 pathway2kegg: Cell cycle - Homo sapiens (human)2biocarta: cell cycle: g1/s check point

Drug-gene GO enrichments

4BP: cellular response to DNA damage stimulus4CC: nucleus4MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding3BP: cell cycle arrest3CC: nucleoplasm3BP: regulation of apoptotic process3MF: DNA binding3BP: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest3BP: positive regulation of gene expression3BP: negative regulation of transcription, DNA-templated

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
472 ATM 2
7157 TP53 4
Showing 1 to 2 of 2 rows

Gene in drug-gene network: Network Plot

Models in AZD6738

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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