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CDK4/CDK6 inhibitor (abemaciclib)
iGMDRD876
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Standard Name
Drug Status
Drug Type
Standard Name
CDK4/CDK6 inhibitor (abemaciclib)
Drug Status
Family
Drug Type
undefined
Drug Class:
Kinase Inhibitor
Protein Kinase Inhibitors
Antineoplastic Agents
Antineoplastic Agents, Phytogenic
Drug-model tissue-cancer distribution: Bubble Plot
LUN
tissue: LUN cancer: LUNG model num: 0
LUNG
tissue: LUNG cancer: Lung Cancer model num: 1
BREAS
tissue: BREAS cancer: BREAST model num: 0
BREAST
tissue: BREAST cancer: Breast Carcinoma model num: 1
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Drug-gene pathway enrichments
4
reactome: Signal Transduction
2
kegg: Longevity regulating pathway - Homo sapiens (human)
2
kegg: Cellular senescence - Homo sapiens (human)
2
kegg: Apoptosis - Homo sapiens (human)
2
kegg: Mitophagy - animal - Homo sapiens (human)
2
kegg: PI3K-Akt signaling pathway - Homo sapiens (human)
2
kegg: Neurotrophin signaling pathway - Homo sapiens (human)
2
kegg: Thyroid hormone signaling pathway - Homo sapiens (human)
2
kegg: Human papillomavirus infection - Homo sapiens (human)
2
kegg: Hepatitis B - Homo sapiens (human)
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Drug-gene GO enrichments
4
BP: positive regulation of gene expression
4
MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding
3
BP: negative regulation of transcription, DNA-templated
3
CC: cytosol
3
BP: negative regulation of cell proliferation
3
BP: positive regulation of transcription by RNA polymerase II
3
CC: cytoplasm
2
CC: nucleoplasm
2
CC: nucleus
2
BP: DNA damage response, signal transduction by p53 class mediator
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Drug-Gene: Aster Plot
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Gene ID
Gene Name
Model Num.
3845
KRAS
1
7157
TP53
1
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4
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Gene in drug-gene network: Network Plot
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Models in CDK4/CDK6 inhibitor (abemaciclib)
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found
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