iGMDRD876


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Standard Name
Drug Status
Drug Type
Standard NameCDK4/CDK6 inhibitor (abemaciclib)
Drug StatusFamily
Drug Typeundefined

Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Lung Cancer model num: 1BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1

Drug-gene pathway enrichments

4reactome: Signal Transduction2kegg: Longevity regulating pathway - Homo sapiens (human)2kegg: Cellular senescence - Homo sapiens (human)2kegg: Apoptosis - Homo sapiens (human)2kegg: Mitophagy - animal - Homo sapiens (human)2kegg: PI3K-Akt signaling pathway - Homo sapiens (human)2kegg: Neurotrophin signaling pathway - Homo sapiens (human)2kegg: Thyroid hormone signaling pathway - Homo sapiens (human)2kegg: Human papillomavirus infection - Homo sapiens (human)2kegg: Hepatitis B - Homo sapiens (human)

Drug-gene GO enrichments

4BP: positive regulation of gene expression4MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding3BP: negative regulation of transcription, DNA-templated3CC: cytosol3BP: negative regulation of cell proliferation3BP: positive regulation of transcription by RNA polymerase II3CC: cytoplasm2CC: nucleoplasm2CC: nucleus2BP: DNA damage response, signal transduction by p53 class mediator

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3845 KRAS 1
7157 TP53 1
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Gene in drug-gene network: Network Plot

Models in CDK4/CDK6 inhibitor (abemaciclib)

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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