ATP5PD
Summary: Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15. [provided by RefSeq, Jun 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
GO terms in ATP5PD
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000274 | mitochondrial proton-transporting ATP synthase, stator stalk |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | HDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005743 | mitochondrial inner membrane |
| CC | TAS | GO:0005743 | mitochondrial inner membrane |
Gene expression in normal tissue: ATP5PD
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ATP5PD
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP111 | Electron Transport Chain |
| wikipathways | WP623 | Oxidative phosphorylation |
| humancyc | PWY-7219 | adenosine ribonucleotides de novo biosynthesis |
| humancyc | PWY-841 | purine nucleotides de novo biosynthesis |
| humancyc | PWY66-409 | superpathway of purine nucleotide salvage |
| pharmgkb | PA165292164 | Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ATP5PD
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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