CTNND1
Summary: This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| catenin delta 1 | MIM:601045 | Ensembl:ENSG00000198561 | HGNC:HGNC:2515 | PA27016 | 11q12.1 |
GO terms in CTNND1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IBA | GO:0045296 | cadherin binding |
| MF | IPI | GO:0045296 | cadherin binding |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IBA | GO:0007043 | cell-cell junction assembly |
| BP | NAS | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007420 | brain development |
| BP | IBA | GO:0009966 | regulation of signal transduction |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | TAS | GO:0034332 | adherens junction organization |
| BP | TAS | GO:0035635 | entry of bacterium into host cell |
| BP | IMP | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IBA | GO:0098609 | cell-cell adhesion |
| BP | IEA | GO:0098609 | cell-cell adhesion |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IMP | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IMP | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005911 | cell-cell junction |
| CC | IDA | GO:0005911 | cell-cell junction |
| CC | IBA | GO:0005913 | cell-cell adherens junction |
| CC | IEA | GO:0005915 | zonula adherens |
| CC | IEA | GO:0030027 | lamellipodium |
| CC | IEA | GO:0030426 | growth cone |
| CC | IDA | GO:0030496 | midbody |
| CC | IEA | GO:0043197 | dendritic spine |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: CTNND1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CTNND1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | arf6_traffickingpathway | Arf6 trafficking events |
| pid | ecadherin_keratinocyte_pathway | E-cadherin signaling in keratinocytes |
| pid | ecadherin_nascentaj_pathway | E-cadherin signaling in the nascent adherens junction |
| pid | ecadherin_stabilization_pathway | Stabilization and expansion of the E-cadherin adherens junction |
| pid | fgf_pathway | FGF signaling pathway |
| pid | ncadherinpathway | N-cadherin signaling events |
| netpath | Pathway_EGFR1 | EGFR1 |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-418990 | Adherens junctions interactions |
| reactome | R-HSA-421270 | Cell-cell junction organization |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-446728 | Cell junction organization |
| reactome | R-HSA-5218920 | VEGFR2 mediated vascular permeability |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-8876384 | Listeria monocytogenes entry into host cells |
| reactome | R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD396 | AS601245 | 1 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD536 | PLX-4720 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CTNND1
CLASSFICATION
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