DVL3
Summary: This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dishevelled segment polarity protein 3 | MIM:601368 | Ensembl:ENSG00000161202 | HGNC:HGNC:3087 | PA27543 | 3q27.1 |
GO terms in DVL3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0002020 | protease binding |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IBA | GO:0005109 | frizzled binding |
| MF | IPI | GO:0005109 | frizzled binding |
| MF | TAS | GO:0005109 | frizzled binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008013 | beta-catenin binding |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0048365 | Rac GTPase binding |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IDA | GO:0016055 | Wnt signaling pathway |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | IMP | GO:0035567 | non-canonical Wnt signaling pathway |
| BP | TAS | GO:0035567 | non-canonical Wnt signaling pathway |
| BP | ISS | GO:0038031 | non-canonical Wnt signaling pathway via JNK cascade |
| BP | IEA | GO:0042493 | response to drug |
| BP | IMP | GO:0043507 | positive regulation of JUN kinase activity |
| BP | IDA | GO:0043547 | positive regulation of GTPase activity |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IGI | GO:0050821 | protein stabilization |
| BP | IBA | GO:0060070 | canonical Wnt signaling pathway |
| BP | IDA | GO:0060070 | canonical Wnt signaling pathway |
| BP | IGI | GO:0060070 | canonical Wnt signaling pathway |
| BP | IMP | GO:0060070 | canonical Wnt signaling pathway |
| BP | TAS | GO:0060070 | canonical Wnt signaling pathway |
| BP | IDA | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |
| BP | NAS | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |
| BP | TAS | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IBA | GO:0090179 | planar cell polarity pathway involved in neural tube closure |
| BP | ISS | GO:0150012 | positive regulation of neuron projection arborization |
| BP | IDA | GO:1903827 | regulation of cellular protein localization |
| BP | TAS | GO:1904886 | beta-catenin destruction complex disassembly |
Gene expression in normal tissue: DVL3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DVL3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201688 | WNT mediated activation of DVL |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-4086400 | PCP/CE pathway |
| reactome | R-HSA-4086400 | PCP/CE pathway |
| reactome | R-HSA-4641258 | Degradation of DVL |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| reactome | R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4150 | Wnt Signaling in Kidney Disease |
| wikipathways | WP4242 | Notch Signaling Pathway |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| pid | betacatenin_deg_pathway | Degradation of beta catenin |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | wnt_canonical_pathway | Canonical Wnt signaling pathway |
| pid | wnt_noncanonical_pathway | Noncanonical Wnt signaling pathway |
| netpath | Pathway_Wnt | Wnt |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD394 | BX-795 | 1 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD214 | AGK 2 | 1 |
| iGMDRD185 | DMOG | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DVL3
CLASSFICATION
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