Summary: This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008].

dishevelled segment polarity protein 3MIM:601368Ensembl:ENSG00000161202HGNC:HGNC:3087PA275433q27.1

GO terms in DVL3

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0002020protease binding
MFIPIGO:0005102signaling receptor binding
MFIBAGO:0005109frizzled binding
MFIPIGO:0005109frizzled binding
MFTASGO:0005109frizzled binding
MFIPIGO:0005515protein binding
MFIDAGO:0008013beta-catenin binding
MFIDAGO:0046982protein heterodimerization activity
MFIPIGO:0048365Rac GTPase binding
CCIDAGO:0000790nuclear chromatin
BPIMPGO:0001934positive regulation of protein phosphorylation
BPIDAGO:0016055Wnt signaling pathway
BPIEAGO:0035556intracellular signal transduction
BPIMPGO:0035567non-canonical Wnt signaling pathway
BPTASGO:0035567non-canonical Wnt signaling pathway
BPISSGO:0038031non-canonical Wnt signaling pathway via JNK cascade
BPIEAGO:0042493response to drug
BPIMPGO:0043507positive regulation of JUN kinase activity
BPIDAGO:0043547positive regulation of GTPase activity
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIGIGO:0050821protein stabilization
BPIBAGO:0060070canonical Wnt signaling pathway
BPIDAGO:0060070canonical Wnt signaling pathway
BPIGIGO:0060070canonical Wnt signaling pathway
BPIMPGO:0060070canonical Wnt signaling pathway
BPTASGO:0060070canonical Wnt signaling pathway
BPIDAGO:0060071Wnt signaling pathway, planar cell polarity pathway
BPNASGO:0060071Wnt signaling pathway, planar cell polarity pathway
BPTASGO:0090090negative regulation of canonical Wnt signaling pathway
BPIBAGO:0090179planar cell polarity pathway involved in neural tube closure
BPISSGO:0150012positive regulation of neuron projection arborization
BPIDAGO:1903827regulation of cellular protein localization
BPTASGO:1904886beta-catenin destruction complex disassembly

Gene expression in normal tissue: DVL3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DVL3

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201688WNT mediated activation of DVL
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-4086400PCP/CE pathway
reactomeR-HSA-4086400PCP/CE pathway
reactomeR-HSA-4641258Degradation of DVL
reactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactomeR-HSA-5368598Negative regulation of TCF-dependent signaling by DVL-interacting proteins
reactomeR-HSA-5663220RHO GTPases Activate Formins
wikipathwaysWP2064Neural Crest Differentiation
wikipathwaysWP268Notch Signaling Pathway
wikipathwaysWP363Wnt Signaling Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4150Wnt Signaling in Kidney Disease
wikipathwaysWP4242Notch Signaling Pathway
wikipathwaysWP428Wnt Signaling Pathway
wikipathwaysWP710DNA Damage Response (only ATM dependent)
pidbetacatenin_deg_pathwayDegradation of beta catenin
pidbetacatenin_nuc_pathwayRegulation of nuclear beta catenin signaling and target gene transcription
pidwnt_canonical_pathwayCanonical Wnt signaling pathway
pidwnt_noncanonical_pathwayNoncanonical Wnt signaling pathway
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04330Notch signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05217Basal cell carcinoma - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DVL3