MGMT


Summary: Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
O-6-methylguanine-DNA methyltransferaseMIM:156569Ensembl:ENSG00000170430HGNC:HGNC:7059PA23910q26.3

GO terms in MGMT


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006266DNA ligation
BPIEAGO:0006306DNA methylation
BPTASGO:0006307DNA dealkylation involved in DNA repair
BPIEAGO:0034599cellular response to oxidative stress
BPIDAGO:0043066negative regulation of apoptotic process
BPIEAGO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIEAGO:0045471response to ethanol
BPIEAGO:0051593response to folic acid
BPIEAGO:0060644mammary gland epithelial cell differentiation
BPIEAGO:0071407cellular response to organic cyclic compound
BPIEAGO:0071479cellular response to ionizing radiation
BPIDAGO:2000781positive regulation of double-strand break repair
CCIBAGO:0005634nucleus
CCTASGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCHDAGO:0016020membrane
MFIEAGO:0003677DNA binding
MFIEAGO:0003908methylated-DNA-[protein]-cysteine S-methyltransferase activity
MFIEAGO:0005509calcium ion binding
MFTASGO:0008168methyltransferase activity
MFTASGO:0009008DNA-methyltransferase activity

Gene expression in normal tissue: MGMT

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MGMT


DatabasePathway IDPathway Des.
pharmgkbPA165374494Busulfan Pathway, Pharmacodynamics
pharmgkbPA2035Cyclophosphamide Pathway, Pharmacodynamics
reactomeR-HSA-5657655MGMT-mediated DNA damage reversal
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-73942DNA Damage Reversal

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD44Temozolomide3
iGMDRD485O(6)-benzylguanine1
iGMDRD13Carmustine1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MGMT

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