MGMT
Summary: Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:156569 Ensembl IDEnsembl:ENSG00000170430 HGNC IDHGNC:HGNC:7059 PHARMGKB IDPA239 Map Location10q26.3 | |||||
GO terms in MGMT
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006266 | DNA ligation |
| BP | IEA | GO:0006306 | DNA methylation |
| BP | TAS | GO:0006307 | DNA dealkylation involved in DNA repair |
| BP | IEA | GO:0034599 | cellular response to oxidative stress |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process |
Gene expression in normal tissue: MGMT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MGMT
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA165374494 | Busulfan Pathway, Pharmacodynamics |
| pharmgkb | PA2035 | Cyclophosphamide Pathway, Pharmacodynamics |
| reactome | R-HSA-5657655 | MGMT-mediated DNA damage reversal |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-73942 | DNA Damage Reversal |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MGMT
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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