MGMT


Summary: Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in MGMT


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0006266 DNA ligation
BP IEA GO:0006306 DNA methylation
BP TAS GO:0006307 DNA dealkylation involved in DNA repair
BP IEA GO:0034599 cellular response to oxidative stress
BP IDA GO:0043066 negative regulation of apoptotic process
BP IEA GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
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Gene expression in normal tissue: MGMT

Gene-model tissue-cancer distribution: Bubble Plot

BRAItissue: BRAI cancer: BRAIN model num: 0BRAINtissue: BRAIN cancer: Glioma model num: 1BRAINtissue: BRAIN cancer: Glioblastoma Multiforme (GBM) model num: 4

Gene-drug pathway distribution

Pathways in MGMT


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Database
Pathway ID
Pathway Des.
pharmgkb PA165374494 Busulfan Pathway, Pharmacodynamics
pharmgkb PA2035 Cyclophosphamide Pathway, Pharmacodynamics
reactome R-HSA-5657655 MGMT-mediated DNA damage reversal
reactome R-HSA-73894 DNA Repair
reactome R-HSA-73942 DNA Damage Reversal
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD44 Temozolomide 3
iGMDRD485 O(6)-benzylguanine 1
iGMDRD13 Carmustine 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MGMT

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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