SOCS1
Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| suppressor of cytokine signaling 1 | MIM:603597 | Ensembl:ENSG00000185338 | HGNC:HGNC:19383 | PA134863068 | 16p13.13 |
GO terms in SOCS1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004860 | protein kinase inhibitor activity |
| MF | IPI | GO:0005159 | insulin-like growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0019210 | kinase inhibitor activity |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IBA | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity |
| BP | ISS | GO:0001932 | regulation of protein phosphorylation |
| BP | IEA | GO:0006469 | negative regulation of protein kinase activity |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | ISS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0038111 | interleukin-7-mediated signaling pathway |
| BP | IEA | GO:0040008 | regulation of growth |
| BP | IMP | GO:0042532 | negative regulation of tyrosine phosphorylation of STAT protein |
| BP | ISS | GO:0042532 | negative regulation of tyrosine phosphorylation of STAT protein |
| BP | ISS | GO:0043372 | positive regulation of CD4-positive, alpha-beta T cell differentiation |
| BP | ISS | GO:0043377 | negative regulation of CD8-positive, alpha-beta T cell differentiation |
| BP | IMP | GO:0045591 | positive regulation of regulatory T cell differentiation |
| BP | IMP | GO:0046426 | negative regulation of JAK-STAT cascade |
| BP | ISS | GO:0046426 | negative regulation of JAK-STAT cascade |
| BP | NAS | GO:0046426 | negative regulation of JAK-STAT cascade |
| BP | IBA | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| BP | ISS | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| BP | IBA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | TAS | GO:0060334 | regulation of interferon-gamma-mediated signaling pathway |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005942 | phosphatidylinositol 3-kinase complex |
| CC | IEA | GO:0031410 | cytoplasmic vesicle |
| CC | IDA | GO:0036464 | cytoplasmic ribonucleoprotein granule |
Gene expression in normal tissue: SOCS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SOCS1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP3935 | Leptin Insulin Overlap |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4197 | The human immune response to tuberculosis |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP581 | EPO Receptor Signaling |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP619 | Type II interferon signaling (IFNG) |
| pid | ifngpathway | IFN-gamma pathway |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Prolactin | Prolactin |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| reactome | R-HSA-1266695 | Interleukin-7 signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-1433559 | Regulation of KIT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-877312 | Regulation of IFNG signaling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-912694 | Regulation of IFNA signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-982772 | Growth hormone receptor signaling |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD63 | Camptothecin | 1 |
| iGMDRD932 | JAK inhibitor | 1 |
| iGMDRD409 | Saracatinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SOCS1
CLASSFICATION
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