SOCS1
Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603597 Ensembl IDEnsembl:ENSG00000185338 HGNC IDHGNC:HGNC:19383 PHARMGKB IDPA134863068 Map Location16p13.13 | |||||
GO terms in SOCS1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004860 | protein kinase inhibitor activity |
| MF | IPI | GO:0005159 | insulin-like growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0019210 | kinase inhibitor activity |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IBA | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity |
Gene expression in normal tissue: SOCS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SOCS1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP3935 | Leptin Insulin Overlap |
| wikipathways | WP395 | IL-4 Signaling Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SOCS1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.