Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008].

suppressor of cytokine signaling 1MIM:603597Ensembl:ENSG00000185338HGNC:HGNC:19383PA13486306816p13.13

GO terms in SOCS1

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004860protein kinase inhibitor activity
MFIPIGO:0005159insulin-like growth factor receptor binding
MFIPIGO:0005515protein binding
MFISSGO:0019210kinase inhibitor activity
MFIPIGO:0019901protein kinase binding
MFIBAGO:00469351-phosphatidylinositol-3-kinase regulator activity
BPISSGO:0001932regulation of protein phosphorylation
BPIEAGO:0006469negative regulation of protein kinase activity
BPIEAGO:0016567protein ubiquitination
BPISSGO:0019221cytokine-mediated signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0035556intracellular signal transduction
BPTASGO:0038111interleukin-7-mediated signaling pathway
BPIEAGO:0040008regulation of growth
BPIMPGO:0042532negative regulation of tyrosine phosphorylation of STAT protein
BPISSGO:0042532negative regulation of tyrosine phosphorylation of STAT protein
BPISSGO:0043372positive regulation of CD4-positive, alpha-beta T cell differentiation
BPISSGO:0043377negative regulation of CD8-positive, alpha-beta T cell differentiation
BPIMPGO:0045591positive regulation of regulatory T cell differentiation
BPIMPGO:0046426negative regulation of JAK-STAT cascade
BPISSGO:0046426negative regulation of JAK-STAT cascade
BPNASGO:0046426negative regulation of JAK-STAT cascade
BPIBAGO:0046627negative regulation of insulin receptor signaling pathway
BPISSGO:0046627negative regulation of insulin receptor signaling pathway
BPIBAGO:0046854phosphatidylinositol phosphorylation
BPTASGO:0060334regulation of interferon-gamma-mediated signaling pathway
CCIBAGO:0005942phosphatidylinositol 3-kinase complex
CCIEAGO:0031410cytoplasmic vesicle
CCIDAGO:0036464cytoplasmic ribonucleoprotein granule

Gene expression in normal tissue: SOCS1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SOCS1

DatabasePathway IDPathway Des.
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP3935Leptin Insulin Overlap
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP4197The human immune response to tuberculosis
wikipathwaysWP481Insulin Signaling
wikipathwaysWP581EPO Receptor Signaling
wikipathwaysWP585Interferon type I signaling pathways
wikipathwaysWP619Type II interferon signaling (IFNG)
pidifngpathwayIFN-gamma pathway
pidil12_2pathwayIL12-mediated signaling events
pidil2_1pathwayIL2-mediated signaling events
pidil4_2pathwayIL4-mediated signaling events
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04930Type II diabetes mellitus - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1433557Signaling by SCF-KIT
reactomeR-HSA-1433559Regulation of KIT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-877312Regulation of IFNG signaling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-909733Interferon alpha/beta signaling
reactomeR-HSA-909733Interferon alpha/beta signaling
reactomeR-HSA-912694Regulation of IFNA signaling
reactomeR-HSA-913531Interferon Signaling
reactomeR-HSA-913531Interferon Signaling
reactomeR-HSA-982772Growth hormone receptor signaling
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD932JAK inhibitor1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SOCS1