ALPP
Summary: The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| alkaline phosphatase, placental | MIM:171800 | Ensembl:ENSG00000163283 | HGNC:HGNC:439 | PA24730 | 2q37.1 |
GO terms in ALPP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0031225 | anchored component of membrane |
| BP | IEA | GO:0016311 | dephosphorylation |
| MF | ISS | GO:0000287 | magnesium ion binding |
| MF | IDA | GO:0004035 | alkaline phosphatase activity |
| MF | NAS | GO:0004035 | alkaline phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0008270 | zinc ion binding |
Gene expression in normal tissue: ALPP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ALPP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00730 | Thiamine metabolism - Homo sapiens (human) |
| kegg | hsa00790 | Folate biosynthesis - Homo sapiens (human) |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-6811438 | Intra-Golgi traffic |
| reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ALPP
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