ALPP


Summary: The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
alkaline phosphatase, placentalMIM:171800Ensembl:ENSG00000163283HGNC:HGNC:439PA247302q37.1

GO terms in ALPP


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005886plasma membrane
CCIDAGO:0009986cell surface
CCIEAGO:0016021integral component of membrane
CCIEAGO:0031225anchored component of membrane
BPIEAGO:0016311dephosphorylation
MFISSGO:0000287magnesium ion binding
MFIDAGO:0004035alkaline phosphatase activity
MFNASGO:0004035alkaline phosphatase activity
MFIPIGO:0005515protein binding
MFISSGO:0008270zinc ion binding

Gene expression in normal tissue: ALPP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ALPP


DatabasePathway IDPathway Des.
kegghsa00730Thiamine metabolism - Homo sapiens (human)
kegghsa00790Folate biosynthesis - Homo sapiens (human)
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-6811438Intra-Golgi traffic
reactomeR-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER traffic

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD131Erlotinib1
iGMDRD133Lapatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ALPP

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