ARFGAP3
Summary: The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
ADP ribosylation factor GTPase activating protein 3 | MIM:612439 | Ensembl:ENSG00000242247 | HGNC:HGNC:661 | PA35024 | 22q13.2 |
Gene Categories:
TRANSPORTERGO terms in ARFGAP3
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0005096 | GTPase activator activity |
MF | IDA | GO:0005096 | GTPase activator activity |
MF | IPI | GO:0005515 | protein binding |
MF | NAS | GO:0008565 | protein transporter activity |
MF | IEA | GO:0046872 | metal ion binding |
CC | IEA | GO:0000139 | Golgi membrane |
CC | IBA | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
CC | IDA | GO:0005794 | Golgi apparatus |
CC | IBA | GO:0005802 | trans-Golgi network |
CC | IDA | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
CC | HDA | GO:0016020 | membrane |
CC | IBA | GO:0030126 | COPI vesicle coat |
BP | NAS | GO:0006886 | intracellular protein transport |
BP | IBA | GO:0006888 | ER to Golgi vesicle-mediated transport |
BP | TAS | GO:0006888 | ER to Golgi vesicle-mediated transport |
BP | IBA | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER |
BP | TAS | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER |
BP | IEP | GO:0009306 | protein secretion |
BP | NAS | GO:0016192 | vesicle-mediated transport |
BP | IEA | GO:0043547 | positive regulation of GTPase activity |
BP | IBA | GO:0048205 | COPI coating of Golgi vesicle |
Gene expression in normal tissue: ARFGAP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARFGAP3
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-199977 | ER to Golgi Anterograde Transport |
reactome | R-HSA-199991 | Membrane Trafficking |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
reactome | R-HSA-5653656 | Vesicle-mediated transport |
reactome | R-HSA-597592 | Post-translational protein modification |
reactome | R-HSA-6807878 | COPI-mediated anterograde transport |
reactome | R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic |
reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
reactome | R-HSA-8856688 | Golgi-to-ER retrograde transport |
reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
biocarta | arappathway | adp-ribosylation factor |
biocarta | rac1pathway | rac1 cell motility signaling pathway |
biocarta | rhopathway | rho cell motility signaling pathway |
biocarta | tcrpathway | t cell receptor signaling pathway |
kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD188 | Piperlongumine | 1 |
iGMDRD588 | HG-5-88-01 | 1 |
iGMDRD434 | BMS-536924 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARFGAP3