ARFGAP3


Summary: The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ADP ribosylation factor GTPase activating protein 3MIM:612439Ensembl:ENSG00000242247HGNC:HGNC:661PA3502422q13.2

Gene Categories:

TRANSPORTER

GO terms in ARFGAP3


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005096GTPase activator activity
MFIDAGO:0005096GTPase activator activity
MFIPIGO:0005515protein binding
MFNASGO:0008565protein transporter activity
MFIEAGO:0046872metal ion binding
CCIEAGO:0000139Golgi membrane
CCIBAGO:0005793endoplasmic reticulum-Golgi intermediate compartment
CCIDAGO:0005794Golgi apparatus
CCIBAGO:0005802trans-Golgi network
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCHDAGO:0016020membrane
CCIBAGO:0030126COPI vesicle coat
BPNASGO:0006886intracellular protein transport
BPIBAGO:0006888ER to Golgi vesicle-mediated transport
BPTASGO:0006888ER to Golgi vesicle-mediated transport
BPIBAGO:0006890retrograde vesicle-mediated transport, Golgi to ER
BPTASGO:0006890retrograde vesicle-mediated transport, Golgi to ER
BPIEPGO:0009306protein secretion
BPNASGO:0016192vesicle-mediated transport
BPIEAGO:0043547positive regulation of GTPase activity
BPIBAGO:0048205COPI coating of Golgi vesicle

Gene expression in normal tissue: ARFGAP3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ARFGAP3


DatabasePathway IDPathway Des.
reactomeR-HSA-199977ER to Golgi Anterograde Transport
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6807878COPI-mediated anterograde transport
reactomeR-HSA-6811434COPI-dependent Golgi-to-ER retrograde traffic
reactomeR-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER traffic
reactomeR-HSA-8856688Golgi-to-ER retrograde transport
reactomeR-HSA-948021Transport to the Golgi and subsequent modification
biocartaarappathwayadp-ribosylation factor
biocartarac1pathwayrac1 cell motility signaling pathway
biocartarhopathwayrho cell motility signaling pathway
biocartatcrpathwayt cell receptor signaling pathway
kegghsa04144Endocytosis - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD188Piperlongumine1
iGMDRD588HG-5-88-011
iGMDRD434BMS-5369241

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARFGAP3

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