ATP5PD
Summary: Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15. [provided by RefSeq, Jun 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ATP synthase peripheral stalk subunit d | Ensembl:ENSG00000167863 | HGNC:HGNC:845 | PA25135 | 17q25.1 |
GO terms in ATP5PD
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000274 | mitochondrial proton-transporting ATP synthase, stator stalk |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | HDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005743 | mitochondrial inner membrane |
| CC | TAS | GO:0005743 | mitochondrial inner membrane |
| CC | IDA | GO:0005753 | mitochondrial proton-transporting ATP synthase complex |
| CC | IEA | GO:0043209 | myelin sheath |
| BP | TAS | GO:0006754 | ATP biosynthetic process |
| BP | IBA | GO:0015986 | ATP synthesis coupled proton transport |
| BP | TAS | GO:0042407 | cristae formation |
| BP | IC | GO:0042776 | mitochondrial ATP synthesis coupled proton transport |
| BP | IEA | GO:0099132 | ATP hydrolysis coupled cation transmembrane transport |
| MF | IDA | GO:0016887 | ATPase activity |
| MF | IC | GO:0022857 | transmembrane transporter activity |
| MF | IBA | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism |
Gene expression in normal tissue: ATP5PD
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ATP5PD
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP111 | Electron Transport Chain |
| wikipathways | WP623 | Oxidative phosphorylation |
| humancyc | PWY-7219 | adenosine ribonucleotides de novo biosynthesis |
| humancyc | PWY-841 | purine nucleotides de novo biosynthesis |
| humancyc | PWY66-409 | superpathway of purine nucleotide salvage |
| pharmgkb | PA165292164 | Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics |
| kegg | hsa00190 | Oxidative phosphorylation - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05012 | Parkinson,s disease - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1592230 | Mitochondrial biogenesis |
| reactome | R-HSA-163200 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| reactome | R-HSA-163210 | Formation of ATP by chemiosmotic coupling |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-8949613 | Cristae formation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD561 | ABT-263 | 1 |
| iGMDRD262 | KU-55933 | 1 |
| iGMDRD49 | Mitomycin | 1 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD587 | CHEMBL585951 | 1 |
| iGMDRD384 | EHT-1864 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ATP5PD
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