ATP5PD


Summary: Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15. [provided by RefSeq, Jun 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ATP synthase peripheral stalk subunit dEnsembl:ENSG00000167863HGNC:HGNC:845PA2513517q25.1

GO terms in ATP5PD


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0000274mitochondrial proton-transporting ATP synthase, stator stalk
CCIDAGO:0005654nucleoplasm
CCHDAGO:0005739mitochondrion
CCIDAGO:0005739mitochondrion
CCIDAGO:0005743mitochondrial inner membrane
CCTASGO:0005743mitochondrial inner membrane
CCIDAGO:0005753mitochondrial proton-transporting ATP synthase complex
CCIEAGO:0043209myelin sheath
BPTASGO:0006754ATP biosynthetic process
BPIBAGO:0015986ATP synthesis coupled proton transport
BPTASGO:0042407cristae formation
BPICGO:0042776mitochondrial ATP synthesis coupled proton transport
BPIEAGO:0099132ATP hydrolysis coupled cation transmembrane transport
MFIDAGO:0016887ATPase activity
MFICGO:0022857transmembrane transporter activity
MFIBAGO:0046933proton-transporting ATP synthase activity, rotational mechanism

Gene expression in normal tissue: ATP5PD

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ATP5PD


DatabasePathway IDPathway Des.
wikipathwaysWP111Electron Transport Chain
wikipathwaysWP623Oxidative phosphorylation
humancycPWY-7219adenosine ribonucleotides de novo biosynthesis
humancycPWY-841purine nucleotides de novo biosynthesis
humancycPWY66-409superpathway of purine nucleotide salvage
pharmgkbPA165292164Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics
kegghsa00190Oxidative phosphorylation - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
kegghsa05012Parkinson,s disease - Homo sapiens (human)
kegghsa05016Huntington,s disease - Homo sapiens (human)
reactomeR-HSA-1428517The citric acid (TCA) cycle and respiratory electron transport
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1592230Mitochondrial biogenesis
reactomeR-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
reactomeR-HSA-163210Formation of ATP by chemiosmotic coupling
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-8949613Cristae formation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD561ABT-2631
iGMDRD262KU-559331
iGMDRD49Mitomycin1
iGMDRD421AZD77621
iGMDRD587CHEMBL5859511
iGMDRD384EHT-18641

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP5PD

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